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Pivots or pistons?

Pakula, Andrew and Simon, Melvin (1992) Pivots or pistons? Nature, 355 (6360). pp. 496-497. ISSN 0028-0836. doi:10.1038/355496a0.

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Transmembrane receptors monitor the extracellular environment and transmit information about changes in specific ligand concentration to the cytoplasm. It is not clear how the message gets across the cell membrane, but one proposal is that ligand binding induces a transmembrane conformational change in the receptor. Writing in Science late last year, members of Kim and Koshland's laboratories reported the determination of the three-dimensional structure of the extracellular domain of Tar, the bacterial aspartate receptor, with and without bound ligand, the hope being that the structures would provide a clear image of the conformational changes involved in signalling. Unfortunately, however, the picture remains blurred.

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Additional Information:© 1992 Nature Publishing Group.
Issue or Number:6360
Record Number:CaltechAUTHORS:20150408-105115909
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56481
Deposited By: Tony Diaz
Deposited On:08 Apr 2015 20:38
Last Modified:10 Nov 2021 20:59

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