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Evidence for two apoptotic pathways in light-induced retinal degeneration

Hao, Wenshan and Wenzel, Andreas and Obin, Martin S. and Chen, Ching-Kang and Brill, Elliott and Krasnoperova, Nataliia V. and Eversole-Cire, Pamela and Kleyner, Yelena and Taylor, Allen and Simon, Melvin I. and Grimm, Christian and Remé, Charlotte E. and Lem, Janis (2002) Evidence for two apoptotic pathways in light-induced retinal degeneration. Nature Genetics, 32 (2). pp. 254-260. ISSN 1061-4036. doi:10.1038/ng984.

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Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some of the complexity underlying the mechanisms that regulate susceptibility to retinal degeneration.

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Additional Information:© 2002 Nature Publishing Group. Received 7 June; accepted 6 August 2002. Published online: 3 September 2002. We thank M. Danciger for help determining leucine/methionine polymorphism in Rpe65; D. Brunelle for help with graphics and manuscript preparation; F. Celestin of the SCOR in Ischemic Heart Disease Histology Core for assistance with histological sections; and D. Greuter, C. Imsand and G. Hoegger for technical assistance. Support for this research was provided by the US National Institutes of Health (J.L., M.I.S. and M.S.O.), Foundation Fighting Blindness (J.L.), Massachusetts Lions Eye Research Fund (an institutional grant to the Department of Ophthalmology, New England Medical Center) and Research to Prevent Blindness Special Scholar’s Award (J.L.). C.E.R. received support from the Swiss National Science Foundation, German Research Council and Velux Foundation.
Funding AgencyGrant Number
Foundation Fighting BlindnessUNSPECIFIED
Massachusetts Lions Eye Research FundUNSPECIFIED
Research to Prevent Blindness Special Scholar’s AwardUNSPECIFIED
Swiss National Science FoundationUNSPECIFIED
German Research CouncilUNSPECIFIED
Velux FoundationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20150408-120149594
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Official Citation:Evidence for two apoptotic pathways in light-induced retinal degeneration pp254 - 260 Wenshan Hao, Andreas Wenzel, Martin S. Obin, Ching-Kang Chen, Elliott Brill, Nataliia V. Krasnoperova, Pamela Eversole-Cire, Yelena Kleyner, Allen Taylor, Melvin I. Simon, Christian Grimm, Charlotte E. Remé & Janis Lem Published online: 03 September 2002 | doi:10.1038/ng984
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56488
Deposited By: Ruth Sustaita
Deposited On:08 Apr 2015 19:32
Last Modified:10 Nov 2021 20:59

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