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Inter-mitochondrial complementation of mtDNA mutations and nuclear context

Attardi, Giuseppe and Enríquez, José A. and Cabezas-Herrera, Juan (2002) Inter-mitochondrial complementation of mtDNA mutations and nuclear context. Nature Genetics, 30 (4). p. 360. ISSN 1061-4036. doi:10.1038/ng0402-360.

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Ono et al. report extensive inter- mitochondrial complementation (transcomplementation) in cell hybrids between two types of respiratory-deficient mitochondria carrying either of two human mtDNA pathogenetic recessive mutations in the genes for tRNA^(Ile) and tRNA^(Leu(UUR)). Nearly all the hybrids exhibited normal mitochondrial protein synthesis and respiratory activity 10 to 14 days after fusion, but not earlier. Their results are in striking contrast with our previous observations, which indicated clearly that complementation between two different deleterious mtDNA mutations carried within distinct organelles in the same human cell could indeed occur, but was a rare phenomenon in the cells analyzed. We wish to point out that the discrepancy between the conclusions of the two laboratories does not concern the issue of whether mammalian mitochondria have the potential to fuse and mix their mtDNA and/or mtDNA products in vivo, an issue on which we do not disagree, but which rather has to do with the generality and frequency of this phenomenon and the importance of its control by the nucleus.

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Additional Information:© 2002 Nature Publishing Group.
Issue or Number:4
Record Number:CaltechAUTHORS:20150408-121803968
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Official Citation:Inter-mitochondrial complementation of mtDNA mutations and nuclear context p360 Giuseppe Attardi, José A. Enriquez & Juan Cabezas-Herrera doi:10.1038/ng0402-360
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56489
Deposited By: Ruth Sustaita
Deposited On:08 Apr 2015 19:43
Last Modified:10 Nov 2021 20:59

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