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Induction of the neural crest: a multigene process

Knecht, Anne K. and Bronner-Fraser, Marianne (2002) Induction of the neural crest: a multigene process. Nature Reviews. Genetics, 3 (6). pp. 453-461. ISSN 1471-0056. doi:10.1038/nrg819.

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In the embryo, the neural crest is an important population of cells that gives rise to diverse derivatives, including the peripheral nervous system and the craniofacial skeleton. Evolutionarily, the neural crest is of interest as an important innovation in vertebrates. Experimentally, it represents an excellent system for studying fundamental developmental processes, such as tissue induction. Classical embryologists have identified interactions between tissues that lead to neural crest formation. More recently, geneticists and molecular biologists have identified the genes that are involved in these interactions; this recent work has revealed that induction of the neural crest is a complex multistep process that involves many genes.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2002 Nature Publishing Group. The authors thank T. Moreno for help with the figures, and M. García-Castro and M. Albrecht for critical reading of the manuscript.
Issue or Number:6
Record Number:CaltechAUTHORS:20150408-145638064
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Official Citation:Induction of the neural crest: a multigene process Anne K. Knecht & Marianne Bronner-Fraser p453 | doi:10.1038/nrg819
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56496
Deposited By: Ruth Sustaita
Deposited On:08 Apr 2015 22:17
Last Modified:10 Nov 2021 21:00

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