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Cyclodextrin-based pharmaceutics: Past, present and future

Davis, Mark E. and Brewster, Marcus E. (2004) Cyclodextrin-based pharmaceutics: Past, present and future. Nature Reviews Drug Discovery, 3 (12). pp. 1023-1035. ISSN 1474-1776. doi:10.1038/nrd1576.

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Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.

Item Type:Article
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Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2004 Nature Publishing Group.
Issue or Number:12
Record Number:CaltechAUTHORS:20150408-151729591
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Official Citation:Cyclodextrin-based pharmaceutics: past, present and future Mark E. Davis & Marcus E. Brewster p1023 | doi:10.1038/nrd1576
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56498
Deposited By: Ruth Sustaita
Deposited On:08 Apr 2015 22:28
Last Modified:10 Nov 2021 21:00

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