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Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

Horvitz, H. Robert and Sternberg, Paul W. (1991) Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. Nature, 351 (6327). pp. 535-541. ISSN 0028-0836. doi:10.1038/351535a0.

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Developmental, genetic and molecular studies indicate that multiple intercellular signalling systems interact to specify the types and spatial patterns of cells generated during the formation of the vulva of the nematode Caenorhabditis elegans. Two classes of evolutionary conserved transmembrane receptors and a Ras protein function in these signalling systems. The biology of vulval development provides a framework for understanding how cell interactions control the development of animals as diverse as nematodes, insects and mammals.

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Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1991 Nature Publishing Group. We thank the members of our laboratories, particularly C. Bargmann and E. Jorgensen. and L. Avery, M. Chalfie. E. Davidson. C. Ferguson, I. Greenwald, B. Herman, I. Herskowltz, C. Kenyon. S. Kim, J. Kimble, K. Struhl and J. White for many helpful suggestions. The work done in our laboratories was supported by the US Public Health Service. H.R.H. and P.W.S. are Investigators of the Howard Hughes Medical Institute.
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U.S. Public Health Service (USPHS)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:6327
Record Number:CaltechAUTHORS:20150410-150918176
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56577
Deposited By: Tony Diaz
Deposited On:11 Apr 2015 00:37
Last Modified:10 Nov 2021 21:01

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