CaltechAUTHORS
  A Caltech Library Service

Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands

Ma, Qiufu and Sommer, Lukas and Cserjesi, Peter and Anderson, David J. (1997) Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands. Journal of Neuroscience, 17 (10). pp. 3644-3652. ISSN 0270-6474. PMCID PMC6573688. https://resolver.caltech.edu/CaltechAUTHORS:20150414-145636277

[img] PDF - Published Version
Creative Commons Attribution.

1327Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150414-145636277

Abstract

Genetic studies in Drosophila and in vertebrates have implicated basic helix-loop-helix (bHLH) genes in neuronal fate determination and cell type specification. We have compared directly the expression of Mash1 and neurogenin1(ngn1), two bHLH genes that are expressed specifically at early stages of neurogenesis. In the PNS these genes are expressed in complementary autonomic and sensory lineages. In the CNS in situ hybridization to serial sections and double-labeling experiments indicate that Mash1 andngn1 are expressed in adjacent and nonoverlapping regions of the neuroepithelium that correspond to future functionally distinct areas of the brain. We also showed that in the PNS several other bHLH genes exhibit similar lineal restriction, as dongn1 and Mash1, suggesting that complementary cascades of bHLH factors are involved in PNS development. Finally, we found that there is a close association between expression of ngn1 and Mash1 and that of two Notch ligands. These observations suggest a basic plan for vertebrate neurogenesis whereby regionalization of the neuroepithelium is followed by activation of a relatively small number of bHLH genes, which are used repeatedly in complementary domains to promote neural determination and differentiation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.17-10-03644.1997DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573688PubMed CentralArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1997 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received Dec. 20, 1996; revised Feb. 19, 1997; accepted March 6, 1997. Q.M. and L.S. are Associates of the Howard Hughes Medical Institute; D.J.A. is an Investigator of the Howard Hughes Medical Institute. We are grateful to Gerry Weinmaster for providing the Jagged probe, to Domingos Henrique for the mouse Dll-1 probe, to Richard Baer for the mouse NSCL1 probe, to Eric Olson and two anonymous reviewers for their helpful comments, and to Tetsu Saito for the double-label in situ hybridization protocol.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:bHLH proteins Mash1 neurogenins Notch ligands neurogenesis cell lineage
Issue or Number:10
PubMed Central ID:PMC6573688
Record Number:CaltechAUTHORS:20150414-145636277
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150414-145636277
Official Citation:Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands. Qiufu Ma, Lukas Sommer, Peter Cserjesi, David J. Anderson. Journal of Neuroscience 15 May 1997, 17 (10) 3644-3652; DOI: 10.1523/JNEUROSCI.17-10-03644.1997
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56650
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:15 Apr 2015 04:19
Last Modified:28 Oct 2019 17:00

Repository Staff Only: item control page