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Deciphering the odorant binding protein - olfactory receptor interactions

Viano, Marilyne and Kim, Soo-Kyung and Goddard, William Andrew, III and de March, Claire and Golebiowski, Jérôme and Fiorucci, Sébastien (2015) Deciphering the odorant binding protein - olfactory receptor interactions. Chemical Senses, 40 (3). p. 242. ISSN 0379-864X. https://resolver.caltech.edu/CaltechAUTHORS:20150414-145753489

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Abstract

Olfactory receptors (OR) belong to the family of GPCR and participate to the recognition of odorants. Prior to the activation of the OR, odorants are disolved in the olfactory mucus by odorant binding proteins (OBP). Belonging to the family of lipocalins, they are small carrier proteins and are considered as non-specific binders. OBP would contribute to the olfaction process by carrying hydrophobic odorant molecules to the OR. Due to the transmembrane nature of these receptors, it remains a hard task to obtain their crystal structure. Molecular modeling methods are perfectly suited to provide relevant three-dimensional models of unknown structures to further gain insights on the structural features of protein-protein complexes. Molecular models of hOR2T4 and rORI7 have been built using both ab initio homology modeling approaches. To understand how OBPs release odorants and participate to the modulation of OR activation, state of the art protein-protein docking [4] have been performed to predict OR-OBP complexes structure (Figure 1). We propose models of interactions showing how rOBP3 is connected to the extracellular loop 2 of hORI7. To decipher the underlying molecular mechanism, molecular dynamics simulations have been carried out to estimate the octanal-rOBP3 free energy of binding. The formation of the OBP-OR complex destabilizes the odorant-OBP interactions prior to the release of the odorant.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1093/chemse/bju073DOIAbstracts
http://chemse.oxfordjournals.org/content/40/3/211PublisherAbstracts
ORCID:
AuthorORCID
Kim, Soo-Kyung0000-0002-4498-5441
Goddard, William Andrew, III0000-0003-0097-5716
Additional Information:© 2015 Oxford University Press.
Issue or Number:3
Record Number:CaltechAUTHORS:20150414-145753489
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150414-145753489
Official Citation:Abstracts from the 24th Annual Meeting of the European Chemoreception Research Organization (ECRO 2014), Dijon, France, September 10-13th, 2014 Chem. Senses (2015) 40 (3): 211-297 doi:10.1093/chemse/bju073
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56651
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Apr 2015 04:21
Last Modified:09 Mar 2020 13:18

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