CaltechAUTHORS
  A Caltech Library Service

Cellular 'neoteny': a possible developmental basis for chromaffin cell plasticity

Anderson, David J. (1989) Cellular 'neoteny': a possible developmental basis for chromaffin cell plasticity. Trends in Genetics, 5 (6). pp. 174-184. ISSN 0168-9525. http://resolver.caltech.edu/CaltechAUTHORS:20150415-080151352

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20150415-080151352

Abstract

Adrenal medullary chromaffin cells, SIF cells and sympathetic neurons are derived from the sympatho-adrenal sublineage of the neural crest, and represent a range of cellular phenotypes extending from endocrine to neuronal. It is suggested here that these cell types may represent different stages of developmental 'arrest' along a linear pathway whose endpoint is a cholinergic sympathetic neuron. This model explains the 'transdifferentiation' of mature cells seen in this system as simply a delayed realization of transitions that normally occur between these stages during development. Such a 'linear model' of phenotypic diversification may be applicable to other developing systems that generate closely related but distinct cell types.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0168-9525(89)90072-3DOIArticle
http://www.sciencedirect.com/science/article/pii/0168952589900723PublisherArticle
Additional Information:© 1989 Published by Elsevier Ltd. I thank Paul Patterson, Story Landis, Martin Raff, Jeremy Brockes, and especially Alison Doupe for their constructive comments on this manuscript. This acknowledgement should not, however, be taken as implying an endorsement by these individuals of the ideas and opinions presented in this paper. I also acknowledge important discussions with Karl Herrup and Gary Freeman, Supported by a Sloan Foundation Fellowship in Neuroscience to D.J.A.
Funders:
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20150415-080151352
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150415-080151352
Official Citation:David J. Anderson, Cellular ‘neoteny’: A possible developmental basis for chromaffin cell plasticity, Trends in Genetics, Volume 5, 1989, Pages 174-184, ISSN 0168-9525, http://dx.doi.org/10.1016/0168-9525(89)90072-3. (http://www.sciencedirect.com/science/article/pii/0168952589900723)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56660
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Apr 2015 04:25
Last Modified:16 Apr 2015 04:25

Repository Staff Only: item control page