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The Neural Crest Cell Lineage Problem: Neuropoiesis?

Anderson, David J. (1989) The Neural Crest Cell Lineage Problem: Neuropoiesis? Neuron, 3 (1). pp. 1-12. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20150415-092313776

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Abstract

The neural crest is a remarkable invention of vertebrate embryogenesis. It consists of a population of precursor cells that detaches from the apical neural tube and then rapidly disperses into the embryo along complex pathways of migration. The proliferating crest cells arrest their migration in various locales where they aggregate to form the sensory and autonomic ganglia of the peripheral nervous system. Neural crest cells also invade developing tissues such as the skin, gut, and adrenal gland to generate differentiated cell populations within these tissues, e.g., melanocytes, enteric neurons, and adrenal medullary chromaffin cells, respectively. The diversity of the cell types derived from the neural crest (Table 1) poses the problem of how uncommitted embryonic cells acquire particular developmental fates.


Item Type:Article
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http://dx.doi.org/10.1016/0896-6273(89)90110-4DOIArticle
http://www.sciencedirect.com/science/article/pii/0896627389901104PublisherArticle
Additional Information:© 1989 by Cell Press. Available online 7 September 2004. I thank J. Carnahan and P. Patterson for sharing their unpublished data. I am also grateful to D. Stemple, J. Sabry, S. Taplitz, and P. Patterson for their critical readings of the manuscript and to P. Patterson for key readings and discussions of hemopoiesis that occurred at the 1988 Cold Spring Harbor summer course on Developmental Neurobiology. Thanks are due also to Ms. Teresa Morales-Oblon and Ms. Anita R. Shaw for their careful and timely preparation of the manuscript and to Tom Jessell and Eric Kandel for sound editorial advice. The writing of this review was supported by a Sloan Foundation Fellowship in Neuroscience.
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Alfred P. Sloan FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20150415-092313776
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150415-092313776
Official Citation:David J. Anderson, The neural crest cell lineage problem: Neuropoiesis?, Neuron, Volume 3, Issue 1, July 1989, Pages 1-12, ISSN 0896-6273, http://dx.doi.org/10.1016/0896-6273(89)90110-4. (http://www.sciencedirect.com/science/article/pii/0896627389901104)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56671
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:15 Apr 2015 22:35
Last Modified:15 Apr 2015 23:37

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