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RPTPδ and the Novel Protein Tyrosine Phosphatase RPTPψ are Expressed in Restricted Regions of the Developing Central Nervous System

Sommer, Lukas and Rao, Mahendra and Anderson, David J. (1997) RPTPδ and the Novel Protein Tyrosine Phosphatase RPTPψ are Expressed in Restricted Regions of the Developing Central Nervous System. Developmental Dynamics, 2008 (1). pp. 48-61. ISSN 1058-8388. https://resolver.caltech.edu/CaltechAUTHORS:20150415-141432839

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Abstract

Transmembrane receptor-type protein tyrosine phosphatases (RPTPs) form a novel and potentially important class of cell regulatory proteins. To identify RPTPs expressed during neural development we have characterized RPTPs transcribed in embryonic day (E)13.5 rat neural tube. Nine different phosphatases, one of which was novel, were identified. We examined the expression of the novel phosphatase, called RPTPψ, and of two other phosphatases, RPTPδ and RPTPμ, whose expression in the developing nervous system has not yet been described in detail. The expression of RPTPμ in small blood capillaries in developing neural tissue is consistent with an involvement in angiogenesis. In contrast, the temporally and spatially regulated expression of RPTPψ and RPTPδ in neuroepithelium suggests a role in early neural development. In the spinal cord, early expression of RPTPδ in the roof plate is followed by its expression in differentiating motor neurons. RPTPψ mRNA is also transiently detectable in the roof plate as well as in floor plate cells. In the telencephalon as well as in the hind-brain at E13.5, the reciprocal expression patterns of RPTPδ and RPTPψ are consistent with a sequential function, RPTPψ exerting its activity in undifferentiated progenitor cells and RPTPδ functioning during neuronal differentiation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/(SICI)1097-0177(199701)208:1<48::AID-AJA5>3.0.CO;2-1DOIArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1997 Wiley-Liss, Inc. Received 10 April 1996; Accepted 2 August 1996. Article first published online: 7 Dec 1998. The authors thank Drs. Andrew Groves and Eric Mercer for critical reading of the manuscript, and Drs. Shin-Shay Tian and Kai Zinn for providing the PCR primer sequences. L.S. was supported by the Swiss Foundation for Medical and Biological Scholarships and is now an Associate of the Howard Hughes Medical Institute; M.R. was an Associate of the Howard Hughes Medical Institute and is now supported by a University of Utah Faculty Development Award. D.J.A. is an Associate Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Swiss Foundation for Medical and Biological ScholarshipsUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
University of UtahUNSPECIFIED
Subject Keywords:receptor-type protein tyrosine phosphatase; roof plate; floor plate; spinal cord; forebrain patterning; neuronal differentiation
Issue or Number:1
Record Number:CaltechAUTHORS:20150415-141432839
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150415-141432839
Official Citation:Sommer, L., Rao, M. and Anderson, D. J. (1997), RPTPδ and the novel protein tyrosine phosphatase RPTPψ are expressed in restricted regions of the developing central nervous system. Dev. Dyn., 208: 48–61. doi: 10.1002/(SICI)1097-0177(199701)208:1<48::AID-AJA5>3.0.CO;2-1
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56690
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:15 Apr 2015 23:46
Last Modified:27 Mar 2020 23:13

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