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Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Receptor

Anderson, D. J. and Blobel, G. (1983) Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Receptor. Cold Spring Harbor Symposia on Quantitative Biology, 48 . pp. 125-134. ISSN 0091-7451. doi:10.1101/SQB.1983.048.01.015.

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The acetylcholine receptor (AChR) has proven the most accessible model system for structure-function studies of a transmitter-activated ion channel (Karlin 1980; Conti-Tronconi and Raftery 1982). However, it also presents a good opportunity to study molecular events in the assembly of a multi-subunit integral membrane protein. Moreover, the synthesis of AChR is regulated during development, both by trophic factors (Jessel et al, 1979) and by activity (Brockes and Hall 1975). To understand the mechanistic bases of these regulatory influences, it would be helpful to know all the molecular events and intermediates in AChR biogenesis. We can presume that these events encompass gene transcription, mRNA processing and transport out of the nucleus, translation, subunit assembly, and intracellular transport of the subunits. The following discussion will concern what we have learned about the stages including and following mRNA translation.

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Anderson, D. J.0000-0001-6175-3872
Additional Information:© 1983 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, This work was supported by a National Science Foundation predoctoral fellowship (to D.J.A.) and a grant from the Muscular Dystrophy Foundation. We thank Drs. Arthur Karlin and Reid Gilmore for helpful discussions during the course of this work.
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NSF predoctoral fellowshipUNSPECIFIED
Muscular Dystrophy FoundationUNSPECIFIED
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Official Citation:Molecular Events in the Synthesis and Assembly of a Nicotinic Acetylcholine Receptor D.J. Anderson and G. Blobel Cold Spring Harb Symp Quant Biol 1983 48: 125-134; doi:10.1101/SQB.1983.048.01.015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56691
Deposited On:15 Apr 2015 23:45
Last Modified:10 Nov 2021 21:02

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