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In Vitro Biosynthesis of the Subunits of Acetylcholine Receptor

Anderson, David J. and Blobel, Günter (1983) In Vitro Biosynthesis of the Subunits of Acetylcholine Receptor. In: Proceedings of the 9th Meeting of the International Neurobiology Society. Progress in Brain Research. No.58. Elsevier , New York, NY, pp. 95-106. ISBN 9780444804327.

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The acetylcholine receptor (AChR) of electric ray and eel is one of the few neurotransmitter receptors to be isolated and extensively characterized. It occupies a unique position in the catalogue of membrane proteins thus far purified, in that it is the only such protein that exhibits both a receptor and an ionophore activity. Located in the post-synaptic plasma membranes of Torpedo electric organ, the AChR is an oligomer of four non-identical subunits. The actual organization of these four polypeptides in the lipid bilayer, and their mechanism of functional interaction, however, is still unknown. The biosynthetic pathway of this molecular complex is an important aspect of the formation and maintenance of neuromuscular junctions. It is, furthermore, a potential paradigm for the manner in which other multi-subunit integral membrane proteins are assembled and transported to the plasmalemma.

Item Type:Book Section
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Anderson, David J.0000-0001-6175-3872
Additional Information:© 1983 Elsevier.
Series Name:Progress in Brain Research
Issue or Number:58
Record Number:CaltechAUTHORS:20150415-151248426
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Official Citation:David J. Anderson, Günter Blobel, In Vitro Biosynthesis of the Subunits of Acetylcholine Receptor, In: J.-P. Changeux, J. Glowinski, M. Imbert and F.E. Bloom, Editor(s), Progress in Brain Research, Elsevier, 1983, Volume 58, Pages 95-106, ISSN 0079-6123, ISBN 9780444804327, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56692
Deposited On:15 Apr 2015 23:43
Last Modified:10 Nov 2021 21:02

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