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MASH-1: A Marker and a Mutation for Mammalian Neural Crest Development

Lo, Liching and Guillemot, François and Joyner, Alexandra L. and Anderson, David J. (1994) MASH-1: A Marker and a Mutation for Mammalian Neural Crest Development. Perspectives on Developmental Neuroscience, 2 (2). pp. 191-201. ISSN 1064-0517.

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The ability to generate mice containing null mutations in any cloned gene promises new insights into the molecular control of mammalian neural crest development. This approach has recently been applied to MASH-1, a transcription factor in the bHLH family that is a mammalian homologue of the Drosophila proneural genes achaete-scute. In wild-type embryos, this gene is expressed early in the development of the autonomic nervous system, in apparent precursors of sympathetic, parasympathetic, and enteric neurons (as well as in restricted regions of the central nervous system). A null mutation in the MASH-1 gene eliminates sympathetic and parasympathetic neurons and enteric neurons of the foregut (esophagus); however, enteric neurons of the stomach and hindgut are only partially affected. Analysis with other markers indicates that the mutation acts after neural crest cells have localized in the anlagen of the autonomic nervous system to prevent neuronal differentiation. The differentiation of autonomic glia appears unaffected. Thus, MASH-1 provides one of the most specific mutations affecting neural development in mammals, as well as a valuable marker to study the early segregation of neural crest cell lineages.

Item Type:Article
Anderson, David J.0000-0001-6175-3872
Additional Information:© 1994 Gordon and Breach, Science Publishers S.A. We thank J. E. Johnson and A. Auerbach for their important contributions to this work, V. Pachnis for communicating his unpublished results and for sharing reagents, and M. Rao for this thoughtful comments on an earlier version of this manuscript. D.J.A. is an Associate Investigator of the Howard Hughes Medical Institute.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:neurogenesis, helix-loop-helix protein, achaete scute
Issue or Number:2
Record Number:CaltechAUTHORS:20150416-100302534
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56719
Deposited By: Ruth Sustaita
Deposited On:16 Apr 2015 17:52
Last Modified:30 Mar 2020 22:19

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