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Development and Plasticity of a Neural Crest-Derived Neuroendocrine Sublineage

Anderson, David J. (1989) Development and Plasticity of a Neural Crest-Derived Neuroendocrine Sublineage. In: The Assembly of the Nervous System. Liss , New York, NY, pp. 17-36. ISBN 9780845115084. http://resolver.caltech.edu/CaltechAUTHORS:20150416-152404808

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Abstract

Neural crest cells migrate from the top of the neural tube and differentiate into a diverse array of cell types after dispersing throughout the embryo. The behavior and fate of this precursor population poses a number of problems at both the cellular and molecular levels. At the cellular level, we wish to know what developmental choices are faced by migrating neural crest cells, and how those choices change at different stages. We also need to know the environmental factors, if any, that act on crest cells to control these choices. Once we know the choices and the factors, at the molecular level, we wish to understand the intracellular circuitry that controls the activation and repression of specific batteries of genes during a developmental decision. We also seek to understand the developmental mechanisms that determine the repertoire of potential fates from which the cell chooses a particular pathway of differentiation. Finally, in those cases where phenotypically stable cells are plastic, we wish to know the conditions that permit such plasticity.


Item Type:Book Section
Additional Information:© 1989 Alan R. Liss, Inc. I wish to thank the many individuals who have contributed to the work described in this review. They include Nozomu Mori , Derek Stemple, and Li-Ching Lo in my own laboratory; Nagesh Mahanthappa and Josette Carnahan in Paul Patterson's laboratory; Paul Henion and Story Landis (Case Western Reserve); and Orit Zigmond and Reuven Stein (Tel Aviv University, Tel Aviv, Israel). This work was supported by NIH grant RO1 NS23476-01 and NSF Presidential Young Investigator and Searle Scholar awards.
Funders:
Funding AgencyGrant Number
NIHRO1 NS23476-01
NSF Presidential Young Investigator AwardUNSPECIFIED
Searle Scholar AwardUNSPECIFIED
Record Number:CaltechAUTHORS:20150416-152404808
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150416-152404808
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56736
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Apr 2015 03:05
Last Modified:17 Apr 2015 03:05

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