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Cell Lineage Determination and the Control of Neuronal Identity in the Neural Crest

Anderson, D. J. and Groves, A. and Lo, L. and Ma, Q. and Shah, N. M. and Sommer, L. (1997) Cell Lineage Determination and the Control of Neuronal Identity in the Neural Crest. Cold Spring Harbor Symposia on Quantitative Biology, 62 . pp. 493-504. ISSN 0091-7451. doi:10.1101/SQB.1997.062.01.056.

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The diverse cell types of complex tissues such as the blood and the brain are generated from self-renewing, multipotent progenitors called stem cells (for reviews, see Hall and Watt 1989; Potten and Loeffler 1990; Morrison et al. 1997). These stem cells must generate progeny of different phenotypes, in the correct proportions, sequence, and location. The manner in which this is accomplished is not well understood. It is clear that the local microenvironment of stem cells has an important influence on their development, as do transcription factors that act within the cells. However, the manner in which such signals and transcription factors interact to control lineage determination by multipotent stem cells is poorly understood. To address this issue, it is necessary to both alter the expression of transcription factors in stem cells and challenge the cells by altering their environment to determine their state of lineage commitment. There are relatively few experimental systems in which such combined genetic and cell biological manipulation of stern cells are feasible.

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Anderson, D. J.0000-0001-6175-3872
Additional Information:© 1997 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, We thank the past members of the Anderson laboratory who have contributed to the work discussed in this paper, including A. Michelsohn. S. Birren. J. Johnson, T. Saito. D. Stemple, J. Verdi. and K. Zimmerman. We also thank our collaborators, including J .-F. Brunet, M.D. Gershon, C. Goridis, F. Guillemot. A. Joyner, C. Kintner, and M. Marchionni, for their important contributions. We are grateful to R. Axel, S. Fraser. A. Ghysen, T. Jessell, P. Patterson, M. Raff, H. Weintraub, B. Wold, and K. Zinn for important discussions. insights. and influences. Portions of the work described here have been supported by the National Institutes of Health Muscular Dystrophy Association, Thailand Foundation for Education and Welfare, Seaver Institute, Swiss National Science Foundation, and Human Frontiers Science Foundation. DJ.A. is an investigator of the Howard Hughes Merucal Institute.
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Foundation for Education and Welfare (Thailand)UNSPECIFIED
Swiss National Science Foundation (SNSF)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Seaver InstituteUNSPECIFIED
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Official Citation:Cell Lineage Determination and the Control of Neuronal Identity in the Neural Crest D.J. Anderson, A. Groves, L. Lo, Q. Ma, M. Rao, N.M. Shah, and L. Sommer Cold Spring Harb Symp Quant Biol 1997 62: 493-504; doi:10.1101/SQB.1997.062.01.056
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56742
Deposited By: Ruth Sustaita
Deposited On:17 Apr 2015 18:58
Last Modified:10 Nov 2021 21:03

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