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Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts

Zhao, Yu and Cao, Hung and Beebe, Tyler and Zhang, Hemin and Zhang, Xiaoxiao and Chang, Honglong and Scremin, Oscar and Lien, Ching-Ling and Tai, Yu-Chong and Hsiai, Tzung K. (2015) Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts. Biomedical Microdevices, 17 (2). Art. No. 40. ISSN 1387-2176 . http://resolver.caltech.edu/CaltechAUTHORS:20150420-153441058

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Abstract

Continuous monitoring of aberrant electrical rhythms during heart injury and repair requires prolonged data acquisition. We hereby developed a wearable microelectrode membrane that could be adherent to the chest of neonatal mice for in situ wireless recording of electrocardiogram (ECG) signals. The novel dry-contact membrane with a meshed parylene-C pad adjacent to the microelectrodes and the expandable meandrous strips allowed for varying size of the neonates. The performance was evaluated at the system level; specifically, the ECG signals (μV) acquired from the microelectrodes underwent two-stage amplification, band-pass filtering, and optical data transmission by an infrared Light Emitting Diode (LED) to the data-receiving unit. The circuitry was prototyped on a printed circuit board (PCB), consuming less than 300 μW, and was completely powered by an inductive coupling link. Distinct P waves, QRS complexes, and T waves of ECG signals were demonstrated from the non-pharmacologically sedated neonates at ~600 beats per minutes. Thus, we demonstrate the feasibility of both real-time and wireless monitoring cardiac rhythms in a neonatal mouse (17–20 mm and <1 g) via dry-contact microelectrode membrane; thus, providing a basis for diagnosing aberrant electrical conduction in animal models of cardiac injury and repair.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10544-014-9912-yDOIArticle
http://link.springer.com/article/10.1007%2Fs10544-014-9912-yPublisherArticle
http://static-content.springer.com/esm/art%3A10.1007%2Fs10544-014-9912-y/MediaObjects/10544_2014_9912_MOESM1_ESM.mp4PublisherSupporting Information
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2015 Springer Science+Business Media New York. The online version of this article (doi:10.1007/s10544-014-9912-y) contains supplementary material, which is available to authorized users. The studies were supported by the National Institutes of Health R01HL-083015 (T.K.H.), R01HD069305-01 (N.C.C., T.K.H.), R01HL111437 (T.K.H.), and R01HL096121(C.L.L.).
Funders:
Funding AgencyGrant Number
NIHR01HL-083015
NIHR01HD069305-01
NIHR01HL111437
NIHR01HL096121
Subject Keywords:Neonatal mice; Wireless monitoring; Dry-contact electrodes; ECG; Heart regeneration
Record Number:CaltechAUTHORS:20150420-153441058
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150420-153441058
Official Citation:Zhao, Y., Cao, H., Beebe, T., Zhang, H., Zhang, X., Chang, H., . . . Hsiai, T. (2015). Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts. Biomedical Microdevices, 17(2), 1-6. doi: 10.1007/s10544-014-9912-y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56791
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:23 Apr 2015 19:46
Last Modified:17 May 2017 21:42

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