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Genomic imprinting of Mash2, a mouse gene required for trophoblast development

Guillemot, François and Caspary, Tamara and Tilghman, Shirley M. and Copeland, Neal G. and Gilbert, Debra J. and Jenkins, Nancy A. and Anderson, David J. and Joyner, Alexandra L. and Rossant, Janet and Nagy, András (1995) Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nature Genetics, 9 (3). pp. 235-242. ISSN 1061-4036. doi:10.1038/ng0395-235.

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The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2- homozygous mutant embryos die at 10 days post−coitum from placental failure. Here we show that Mash2 is genomically imprinted. First, Mash2+/- embryos inheriting a wild−type allele from their father die at the same stage as -/- embryos, with a similar placental phenotype. Second, the Mash2 paternal allele is initially expressed by groups of trophoblast cells at 6.5 and 7.5 days post−coitum, but appears almost completely repressed by 8.5 days post−coitum. Finally, we have genetically and physically mapped Mash2 to the distal region of chromosome 7, within a cluster of imprinted genes, including insulin−2, insulin−like growth factor−2 and H19.

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Anderson, David J.0000-0001-6175-3872
Additional Information:©.1995 Nature Publishing Group. Received 23 November; accepted 1 January 1995. We thank K. Harpal, A. Freer and B. Cho for excellent technical assistance. This research was supported in part by grants from the National Cancer Institute of Canada and Bristol-Myers Squibb Limited (A.L.J.), the Medical Research Council of Canada (J.R.), an ATIPE from Centre National de la Recherche Scientifique (CNRS)(F.G.), a grant from the National Cancer Institute, DHHS under contract NOI-CO-46000 with ABL (N.G.C.,N.A.J.). F.G. was supported in part by a fellowship from the MRC of Canada and CNRS, S.M.T. is an investigator, D.J.A. is an Associate Investigator and J.R. and A.L.J. are International Scholars of the Howard Hughes Medical Institute. J.R. is a Terry Fox Research Scientist of the NCIC and A.L.J. was a MRC Scientist.
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National Cancer Institute of CanadaUNSPECIFIED
Bristol-Myers Squibb LimitedUNSPECIFIED
Medical Research Council of CanadaUNSPECIFIED
Centre National de la Recherche Scientifique (CNRS)UNSPECIFIED
National Cancer InstituteNOI-CO-46000
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
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Official Citation:Genomic imprinting of Mash2, a mouse gene required for trophoblast development pp235 - 242 François Guillemot, Tamara Caspary, Shirley M. Tilghman, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, David J. Anderson, Alexandra L. Joyner, Janet Rossant & András Nagy doi:10.1038/ng0395-235
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56815
Deposited By: Ruth Sustaita
Deposited On:21 Apr 2015 19:22
Last Modified:10 Nov 2021 21:04

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