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Becoming a new neuron in the adult olfactory bulb

Carleton, Alan and Petreanu, Leopoldo T. and Lansford, Rusty and Alvarez-Buylla, Arturo and Lledo, Pierre-Marie (2003) Becoming a new neuron in the adult olfactory bulb. Nature Neuroscience, 6 (5). pp. 507-518. ISSN 1097-6256. doi:10.1038/nn1048.

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New neurons are continually recruited throughout adulthood in certain regions of the adult mammalian brain. How these cells mature and integrate into preexisting functional circuits remains unknown. Here we describe the physiological properties of newborn olfactory bulb interneurons at five different stages of their maturation in adult mice. Patch-clamp recordings were obtained from tangentially and radially migrating young neurons and from neurons in three subsequent maturation stages. Tangentially migrating neurons expressed extrasynaptic GABAA receptors and then AMPA receptors, before NMDA receptors appeared in radially migrating neurons. Spontaneous synaptic activity emerged soon after migration was complete, and spiking activity was the last characteristic to be acquired. This delayed excitability is unique to cells born in the adult and may protect circuits from uncontrolled neurotransmitter release and neural network disruption. Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.

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URLURL TypeDescription Information Readcube access
Carleton, Alan0000-0001-5633-9159
Petreanu, Leopoldo T.0000-0003-1434-4691
Lansford, Rusty0000-0002-2159-3699
Alvarez-Buylla, Arturo0000-0003-4426-8925
Lledo, Pierre-Marie0000-0002-8156-7003
Additional Information:© 2003 Nature Publishing Group. Received 6 February; Accepted 11 March 2003. This work was supported by the Pasteur Institute, the Annette Gruner-Schlumberger Foundation, the CNRS, the Fondation pour la Recherché Médicale, a grant from the French Ministry of Research and Education (ACI Biologie du Développement et Physiologie Intégrative 2000) and by a National Institutes of Health grant HD32116. We thank E. Perret and M.M. Gabellec for technical help with the confocal microscope and immunocytochemistry, respectively. We also thank A. Saghatelyan, M. Davenne and I. Manns for critical reading of the manuscript.
Funding AgencyGrant Number
Pasteur InstituteUNSPECIFIED
Annette Gruner-Schlumberger FoundationUNSPECIFIED
Centre National de la Recherche Scientifique (CNRS)UNSPECIFIED
Fondation pour la Recherche MédicaleUNSPECIFIED
ACI Biologie du Développement et Physiologie Intégrative 2000UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20150422-114741426
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Official Citation:Carleton, A., Petreanu, L. T., Lansford, R., Alvarez-Buylla, A., & Lledo, P.-M. (2003). Becoming a new neuron in the adult olfactory bulb. [10.1038/nn1048]. Nat Neurosci, 6(5), 507-518.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:56878
Deposited On:22 Apr 2015 22:38
Last Modified:10 Nov 2021 21:04

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