CaltechAUTHORS
  A Caltech Library Service

Properties of Photogenerated Tryptophan and Tyrosyl Radicals in Structurally Characterized Proteins Containing Rhenium(I) Tricarbonyl Diimines

Di Bilio, Angel J. and Crane, Brian R. and Wehbi, William A. and Kiser, Cynthia N. and Abu-Omar, Mahdi M. and Carlos, Rose M. and Richards, John H. and Winkler, Jay R. and Gray, Harry B. (2001) Properties of Photogenerated Tryptophan and Tyrosyl Radicals in Structurally Characterized Proteins Containing Rhenium(I) Tricarbonyl Diimines. Journal of the American Chemical Society, 123 (13). pp. 3181-3182. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20150428-143033571

[img] PDF - Supplemental Material
See Usage Policy.

157Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150428-143033571

Abstract

Aromatic amino acid radicals are key intermediates in nucleic acid biosynthesis, DNA repair, dioxygen reduction by cytochrome oxidase, water oxidation by PSII, as well as other biological procesess. In our work on electron tunneling in proteins, we have developed laser flash/quench methods that potentially could facilitate the study of such highly reactive radicals. To test our methods, we are investigating two structurally characterized proteins, [Re(CO)_3(L)(H83)]^+AzM^(2+) and [Re(CO)_3(L)(H107)]^+AzM^(2+) (L ) 1,10-phenanthroline (phen) or 4,7-Me_2phen; Az ) Pseudomonas aeruginosa azurin; M ) Cu or Zn). Of special interest is that calculations and experiments on the H107 protein show that Cu^+ oxidation via electron transfer (ET) through an intervening tyrosine (Cu^+ → Y108^(./) → Re(2+)) is over 2 orders of magnitude faster than optimized (Cu^+ → Re^(2+)) electron tunneling.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja0043183DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja0043183PublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/ja0043183PublisherSupporting Information
ORCID:
AuthorORCID
Kiser, Cynthia N.0000-0002-0102-996X
Winkler, Jay R.0000-0002-4453-9716
Gray, Harry B.0000-0002-7937-7876
Additional Information:© 2001 American Chemical Society. Received December 22, 2000. Dedicated to the memory of Jerry Babcock (1946- 2000). Jerry was an enthusiastic colleague and dear friend who helped us in many different ways during the course of this work. He was a master teacher as well as a brilliant scholar, and we will forever be indebted to him for his guidance. Supported by NIH (DK19038 to H.B.G.; GM16424 to J.H.R.).
Funders:
Funding AgencyGrant Number
NIHDK19038
NIHGM16424
Issue or Number:13
Record Number:CaltechAUTHORS:20150428-143033571
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150428-143033571
Official Citation:Di Bilio, A. J., Crane, B. R., Wehbi, W. A., Kiser, C. N., Abu-Omar, M. M., Carlos, R. M., . . . Gray, H. B. (2001). Properties of Photogenerated Tryptophan and Tyrosyl Radicals in Structurally Characterized Proteins Containing Rhenium(I) Tricarbonyl Diimines. Journal of the American Chemical Society, 123(13), 3181-3182. doi: 10.1021/ja0043183
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57058
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:29 Apr 2015 20:01
Last Modified:22 Nov 2019 09:58

Repository Staff Only: item control page