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Substrates for fumarate hydratase

Nigh, Wesley G. and Richards, John H. (1969) Substrates for fumarate hydratase. Journal of the American Chemical Society, 91 (21). pp. 5847-5848. ISSN 0002-7863. doi:10.1021/ja01049a025.

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Fluorofumaric acid and difluorofumaric acid are found to be substrates for fumarate hydratase. The direction of addition of water to fluorofumarate and, more importantly, the relative reactivities of fluorofumarate and difluorofumarate support a mechanism for the hydration reaction that involves a carbonium ion type intermediate. Neither 2-(S)-2-methoxysuccinic nor 2-(S)-2-acetoxysuccinic acid nor mono- or difluoromaleic acid are substrates for fumarate hydratase.

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Additional Information:© 1969 American Chemical Society. Received January 10, 1969. We thank the National Institutes of Health of the U.S. Public Health Service (Grant GM-10218) for support of this research.
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Issue or Number:21
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Official Citation:Substrates for fumarate hydratase Wesley G. Nigh and John H. Richards Journal of the American Chemical Society 1969 91 (21), 5847-5848 DOI: 10.1021/ja01049a025
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57079
Deposited By: Tony Diaz
Deposited On:01 May 2015 17:19
Last Modified:10 Nov 2021 21:07

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