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Substrates for fumarate hydratase

Nigh, Wesley G. and Richards, John H. (1969) Substrates for fumarate hydratase. Journal of the American Chemical Society, 91 (21). pp. 5847-5848. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20150429-084340544

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Abstract

Fluorofumaric acid and difluorofumaric acid are found to be substrates for fumarate hydratase. The direction of addition of water to fluorofumarate and, more importantly, the relative reactivities of fluorofumarate and difluorofumarate support a mechanism for the hydration reaction that involves a carbonium ion type intermediate. Neither 2-(S)-2-methoxysuccinic nor 2-(S)-2-acetoxysuccinic acid nor mono- or difluoromaleic acid are substrates for fumarate hydratase.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja01049a025 DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja01049a025PublisherArticle
Additional Information:© 1969 American Chemical Society. Received January 10, 1969. We thank the National Institutes of Health of the U.S. Public Health Service (Grant GM-10218) for support of this research.
Funders:
Funding AgencyGrant Number
NIHGM-10218
Issue or Number:21
Record Number:CaltechAUTHORS:20150429-084340544
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150429-084340544
Official Citation:Substrates for fumarate hydratase Wesley G. Nigh and John H. Richards Journal of the American Chemical Society 1969 91 (21), 5847-5848 DOI: 10.1021/ja01049a025
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57079
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 May 2015 17:19
Last Modified:03 Oct 2019 08:20

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