Jayme, Manfred and Richards, John H. (1971) Mechanism of action of coenzyme B_(12). Release of 5′-deoxyinosine on incubation of deoxyinosylcobalamin, 1,2-propanediol and propanediol dehydrase. Biochemical and Biophysical Research Communications, 43 (6). pp. 1329-1333. ISSN 0006-291X. doi:10.1016/S0006-291X(71)80018-9. https://resolver.caltech.edu/CaltechAUTHORS:20150429-085524057
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Abstract
We wish to report evidence that the covalent bond in coenzyme B_(12) between the cobalt atom and the methylene group (C-5′) of the nucleoside moiety is cleaved during enzymatic conversion of 1,2-propanediol to propionaldehyde. Acquisition of a third hydrogen satisfies the valence at C-5′ created by the cobalt-C-5′ bond cleavage; C-5′ is thus converted to a methyl group. The experimental result to support this assertion is the observation that mixtures of 1,2-propanediol, propanediol dehydrase and deoxyinosylcobalamin liberate 5′-deoxyinosine to solution.
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| Additional Information: | © 1971 Published by Elsevier Inc. Received 6 May 1971, Available online 6 April 2005. Supported by the National Institutes of Health Grant GMS-10218. We should like to thank the National Institutes of Health for financial support of this work and Professor R. H. Abeles of Brandeis for a generous gift of propanediol dehydrase. | |||||||||
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| Issue or Number: | 6 | |||||||||
| DOI: | 10.1016/S0006-291X(71)80018-9 | |||||||||
| Record Number: | CaltechAUTHORS:20150429-085524057 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150429-085524057 | |||||||||
| Official Citation: | Manfred Jayme, John H. Richards, Mechanism of action of coenzyme B12. Release of 5′-deoxyinosine on incubation of deoxyinosylcobalamin, 1,2-propanediol and propanediol dehydrase, Biochemical and Biophysical Research Communications, Volume 43, Issue 6, 18 June 1971, Pages 1329-1333, ISSN 0006-291X, http://dx.doi.org/10.1016/S0006-291X(71)80018-9. (http://www.sciencedirect.com/science/article/pii/S0006291X71800189) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57081 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 29 Apr 2015 16:11 | |||||||||
| Last Modified: | 10 Nov 2021 21:07 |
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