Schmidt, Donald E., Jr. and Nigh, Wesley G. and Tanzer, Christian and Richards, John H. (1969) Secondary isotope effects in dehydration of malic acid by fumarate hydratase. Journal of the American Chemical Society, 91 (21). pp. 5849-5854. ISSN 0002-7863. doi:10.1021/ja01049a026. https://resolver.caltech.edu/CaltechAUTHORS:20150429-094618091
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Abstract
The kinetic isotope effects for the dehydration by fumarate hydratase of 2-^3H-1,4-^(14)Cl-/-malic acid and 2,3-^3H-1,4-^(14)C-l-malic acid have been determined and support a carbonium ion mechanism for the enzymatic reaction. The isotope effect on the equilibrium between l-malate and fumarate has also been determined experimentally and agrees closely with that anticipated on the basis of a Bigeleisen treatment.
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| Additional Information: | © 1969 American Chemical Society. We should like to thank the National Institutes of Health of the U.S. Public Health Service (Grant GM-10218) for support of this research and Professor J. D. Roberts for a useful suggestion. | |||||||||
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| Issue or Number: | 21 | |||||||||
| DOI: | 10.1021/ja01049a026 | |||||||||
| Record Number: | CaltechAUTHORS:20150429-094618091 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150429-094618091 | |||||||||
| Official Citation: | Secondary isotope effects in dehydration of malic acid by fumarate hydratase Donald E. Schmidt Jr., Wesley G. Nigh, Christian Tanzer, and John H. Richards Journal of the American Chemical Society 1969 91 (21), 5849-5854 DOI: 10.1021/ja01049a026 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57085 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 29 Apr 2015 17:37 | |||||||||
| Last Modified: | 10 Nov 2021 21:07 |
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