Dalbadie-McFarland, G. and Riggs, A. D. and Richards, J. H. (1984) Directed mutagenesis as a technique to study protein function: application to β-lactamase. Biochemical Society Transactions, 12 (2). pp. 226-228. ISSN 1470-8752. doi:10.1042/bst0120226. https://resolver.caltech.edu/CaltechAUTHORS:20150430-084326616
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Abstract
The function of a protein follows uniquely from its three-dimensional structure, which is unambiguously determined by the linear sequence of amino acids. Thus to undertake a systematic study of the relationship between protein structure and function, one would ideally like to be able to alter the structural gene in various ways to encode proteins with novel sequences, structures and functions. Various mutagenic strategies and methods have recently been developed that allow one to achieve these objectives.
Item Type: | Article | |||||||||
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Additional Information: | © 1984 Biochemical Society. | |||||||||
Issue or Number: | 2 | |||||||||
DOI: | 10.1042/bst0120226 | |||||||||
Record Number: | CaltechAUTHORS:20150430-084326616 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150430-084326616 | |||||||||
Official Citation: | Directed mutagenesis as a technique to study protein function: application to β-lactamase G. DALBADIE‑McFARLAND, A. D. RIGGS and J. H. RICHARDS..........226‑228 doi:10.1042/bst0120226 | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 57104 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Ruth Sustaita | |||||||||
Deposited On: | 30 Apr 2015 20:27 | |||||||||
Last Modified: | 10 Nov 2021 21:08 |
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