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Directed mutagenesis as a technique to study protein function: application to β-lactamase

Dalbadie-McFarland, G. and Riggs, A. D. and Richards, J. H. (1984) Directed mutagenesis as a technique to study protein function: application to β-lactamase. Biochemical Society Transactions, 12 (2). pp. 226-228. ISSN 1470-8752. https://resolver.caltech.edu/CaltechAUTHORS:20150430-084326616

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Abstract

The function of a protein follows uniquely from its three-dimensional structure, which is unambiguously determined by the linear sequence of amino acids. Thus to undertake a systematic study of the relationship between protein structure and function, one would ideally like to be able to alter the structural gene in various ways to encode proteins with novel sequences, structures and functions. Various mutagenic strategies and methods have recently been developed that allow one to achieve these objectives.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1042/bst0120226DOIArticle
http://www.biochemsoctrans.org/bst/012/bst0120226.htmPublisherArticle
Additional Information:© 1984 Biochemical Society.
Issue or Number:2
Record Number:CaltechAUTHORS:20150430-084326616
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150430-084326616
Official Citation:Directed mutagenesis as a technique to study protein function: application to β-lactamase G. DALBADIE‑McFARLAND, A. D. RIGGS and J. H. RICHARDS..........226‑228 doi:10.1042/bst0120226
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57104
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:30 Apr 2015 20:27
Last Modified:03 Oct 2019 08:21

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