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Metastasis Upregulated Genes Have Distinct Function in C. elegans Cell Migrations

Vetrone, S. A. and Kato, M. and Sternberg, P. (2014) Metastasis Upregulated Genes Have Distinct Function in C. elegans Cell Migrations. In: 2014 ASCB: an International Forum for Cell Biology, December, 2014, Philadelphia, PA.

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Cell migration is vital for normal animal development but also contributes to the invasive spreading of early stage metastatic cancer. From two published databases, we complied 107 genes unregulated in either breast cancer or melanoma metastases and investigated their requirement in two Caenorhabditis elegans cell migrations: the male linker cell (LC) and hermaphrodite distal tip cells (DTC) which have similar functions as gonadal leader cells that undergo a complex migration while pulling non-motile followers. We performed an RNAi screen to identify genes implicated in normal LC and DTC migrations. Thirty-two genes from the metastasis list were required for the cell migration of which 13 genes effected the migration of both LC and DTC, 18 genes effected only LC migration, and 4 genes only DTC migration. The genes used by both cell types corresponded to genes involved in cell cycle activity, adhesion, cytoskeleton organization, protein degradation activity, spliceosome activity, ubiquitin-like modification and function, and peptidase inhibition. The genes used by only the LC corresponded to genes involved in adhesion, cytoskeletal organization, methyltransferase activity, metalloproteinase activity, and signaling. Those genes used by only DTC corresponded to genes involved in signaling, peptidase inhibition, and utrophin activity. The significant differences among the developmental cell migrations and the overlap in genes shared between the two metastases underscores the value of characterizing diverse genes and considering cell type in developing treatments.

Item Type:Conference or Workshop Item (Poster)
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URLURL TypeDescription
Vetrone, S. A.0000-0002-5521-0959
Kato, M.0000-0003-3827-8879
Sternberg, P.0000-0002-7699-0173
Additional Information:© 2014 American Society for Cell Biology. POSTER PRESENTATIONS- Sunday, December 7.
Record Number:CaltechAUTHORS:20150504-132426990
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57201
Deposited By: Ruth Sustaita
Deposited On:06 May 2015 17:49
Last Modified:09 Mar 2020 13:19

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