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Magnetic resonance studies of the binding of ^(13)C-labeled carbon monoxide to myoglobins and hemoglobins containing modified hemes

Moon, Richard B. and Dill, Kilian and Richards, John H. (1977) Magnetic resonance studies of the binding of ^(13)C-labeled carbon monoxide to myoglobins and hemoglobins containing modified hemes. Biochemistry, 16 (2). pp. 221-228. ISSN 0006-2960. http://resolver.caltech.edu/CaltechAUTHORS:20150504-150820233

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Abstract

The effects of changes in the groups attached to the periphery of the porphyrin ring of the heme of various hemoglobins and myoglobins on the environment experienced by the ligand, carbon monoxide, have been studied by observation of the chemical shift of the bound ^(13)CO. The results indicate that the major interaction between bound ligand and substituents around the porphyrin is that transmitted electronically from substituent to ligand. The nature of the protein environment around the ligand and the interaction between the proximal histidine (F8) and the ligand (through the iron atom) impose differences between subunits of hemoglobin and between myoglobins and hemoglobins which are largely, but not entirely, independent of these substituent effects. To assess the influence of protein structure on the chemical shifts of bound ligand, the shifts of ^(13)CO bound to myoglobin and hemoglobins from a wide range of species have also been measured.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bi00621a010 DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bi00621a010PublisherArticle
Additional Information:© 1977 American Chemical Society. Received April 19, 1976. Supported by grants from the United States Public Health Service (NIHL 15196 and NIHL 15162).
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)NIHL 15196
U.S. Public Health Service (USPHS)NIHL 15162
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Caltech Division of Chemistry and Chemical Engineering5315
Record Number:CaltechAUTHORS:20150504-150820233
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150504-150820233
Official Citation:Magnetic resonance studies of the binding of 13C-labeled carbon monoxide to myoglobins and hemoglobins containing modified hemes Richard B. Moon, Kilian Dill, and John H. Richards Biochemistry 1977 16 (2), 221-228 DOI: 10.1021/bi00621a010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57211
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 May 2015 16:53
Last Modified:06 May 2015 16:53

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