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^(13)C magnetic resonance studies of the binding of carbon monoxide to various hemoglobins

Moon, Richard B. and Richards, John H. (1974) ^(13)C magnetic resonance studies of the binding of carbon monoxide to various hemoglobins. Biochemistry, 13 (17). pp. 3437-3443. ISSN 0006-2960. https://resolver.caltech.edu/CaltechAUTHORS:20150504-153247897

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Abstract

Carbon monoxide binding to hemoglobins from a variety of sources has been studied by ^(13)C nuclear magnetic resonance. The two resonances have been specifically assigned to ^(13)CO bound to α or to β subunits. The reason for the anomalous shift of ^(13)CO bound to the a chain of rabbit hemoglobin is discussed with particular reference to residue Phe-48 (CD6). The relative facility with which oxygen displaces carbon monoxide, and the relative thermodynamic affinity for carbon monoxide compared to the unliganded state, of the α and β subunits are found to differ.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bi00714a003DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bi00714a003PublisherArticle
Additional Information:© 1974 American Chemical Society. Received October 16, 1973. Supported by U.S. Public Health Service Grants NIHL 15198 and NIHL 15162. We thank M. Nelson for assistance with the chain separations and F. Brown for electrophoresis studies. We also wish to thank Dr. D. Powars of the Los Angeles County-USC Medical Center for providing samples of sickle cell and fetal blood.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)NIHL 15198
U.S. Public Health Service (USPHS)NIHL 15162
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Caltech Church Laboratory of Chemical Biology4774
Issue or Number:17
Record Number:CaltechAUTHORS:20150504-153247897
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150504-153247897
Official Citation:Carbon-13 magnetic resonance studies of the binding of carbon monoxide to various hemoglobins Richard B. Moon and John H. Richards Biochemistry 1974 13 (17), 3437-3443 DOI: 10.1021/bi00714a003
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57212
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 May 2015 16:45
Last Modified:03 Oct 2019 08:22

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