Moon, Richard B. and Richards, John H. (1974) ^(13)C magnetic resonance studies of the binding of carbon monoxide to various hemoglobins. Biochemistry, 13 (17). pp. 3437-3443. ISSN 0006-2960. doi:10.1021/bi00714a003. https://resolver.caltech.edu/CaltechAUTHORS:20150504-153247897
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20150504-153247897
Abstract
Carbon monoxide binding to hemoglobins from a variety of sources has been studied by ^(13)C nuclear magnetic resonance. The two resonances have been specifically assigned to ^(13)CO bound to α or to β subunits. The reason for the anomalous shift of ^(13)CO bound to the a chain of rabbit hemoglobin is discussed with particular reference to residue Phe-48 (CD6). The relative facility with which oxygen displaces carbon monoxide, and the relative thermodynamic affinity for carbon monoxide compared to the unliganded state, of the α and β subunits are found to differ.
| Item Type: | Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Related URLs: |
| |||||||||
| Additional Information: | © 1974 American Chemical Society. Received October 16, 1973. Supported by U.S. Public Health Service Grants NIHL 15198 and NIHL 15162. We thank M. Nelson for assistance with the chain separations and F. Brown for electrophoresis studies. We also wish to thank Dr. D. Powars of the Los Angeles County-USC Medical Center for providing samples of sickle cell and fetal blood. | |||||||||
| Funders: |
| |||||||||
| Other Numbering System: |
| |||||||||
| Issue or Number: | 17 | |||||||||
| DOI: | 10.1021/bi00714a003 | |||||||||
| Record Number: | CaltechAUTHORS:20150504-153247897 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150504-153247897 | |||||||||
| Official Citation: | Carbon-13 magnetic resonance studies of the binding of carbon monoxide to various hemoglobins Richard B. Moon and John H. Richards Biochemistry 1974 13 (17), 3437-3443 DOI: 10.1021/bi00714a003 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57212 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 06 May 2015 16:45 | |||||||||
| Last Modified: | 10 Nov 2021 21:09 |
Repository Staff Only: item control page
