Moon, Richard B. and Nelson, Mark J. and Richards, John H. and Powars, Darleen F. (1974) ^(13)C Magnetic Resonance Studies of Hemoglobin Carbamylation. Physiological Chemistry and Physics, 6 (1). pp. 31-40. ISSN 0031-9325. https://resolver.caltech.edu/CaltechAUTHORS:20150505-081223308
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Abstract
^(13)C magnetic resonance techniques have been used to study the reaction of ^(13)C-enriched cyanate with human adult and sickle cell hemoglobin. The carbamyl resonances from carbamylated hemoglobin are assigned on the basis of chemical evidence and comparisons with model amino acid and peptide derivatives. Carbamylation of the α-amino groups of the N-terminal valine residues shows considerable pH dependence in the range 6.7-8.2 while carbamylation of the e-amino groups of the lysine residues is relatively pH independent. Spin-lattice relaxation time and nuclear Overhauser effect measurements for carbamyl carbons are reported.
| Item Type: | Article | ||||||
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| Additional Information: | © 1974 International Society for Supramolecular Biology. Received January 21, 1974. This work was supported by U. S. Public Health Service Grants NIHL 15198 and NIHL 15162. | ||||||
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| Issue or Number: | 1 | ||||||
| Record Number: | CaltechAUTHORS:20150505-081223308 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150505-081223308 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 57215 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 05 May 2015 19:54 | ||||||
| Last Modified: | 03 Oct 2019 08:22 |
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