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^(13)C Magnetic Resonance Studies of Hemoglobin Carbamylation

Moon, Richard B. and Nelson, Mark J. and Richards, John H. and Powars, Darleen F. (1974) ^(13)C Magnetic Resonance Studies of Hemoglobin Carbamylation. Physiological Chemistry and Physics, 6 (1). pp. 31-40. ISSN 0031-9325.

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^(13)C magnetic resonance techniques have been used to study the reaction of ^(13)C-enriched cyanate with human adult and sickle cell hemoglobin. The carbamyl resonances from carbamylated hemoglobin are assigned on the basis of chemical evidence and comparisons with model amino acid and peptide derivatives. Carbamylation of the α-amino groups of the N-terminal valine residues shows considerable pH dependence in the range 6.7-8.2 while carbamylation of the e-amino groups of the lysine residues is relatively pH independent. Spin-lattice relaxation time and nuclear Overhauser effect measurements for carbamyl carbons are reported.

Item Type:Article
Additional Information:© 1974 International Society for Supramolecular Biology. Received January 21, 1974. This work was supported by U. S. Public Health Service Grants NIHL 15198 and NIHL 15162.
Funding AgencyGrant Number
U. S. Public Health Service (USPHS)NIHL 15198
U. S. Public Health Service (USPHS)NIHL 15162
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Caltech Division of Chemistry and Chemical Engineering4717
Issue or Number:1
Record Number:CaltechAUTHORS:20150505-081223308
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57215
Deposited By: Tony Diaz
Deposited On:05 May 2015 19:54
Last Modified:03 Oct 2019 08:22

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