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Neutral particle mass spectrometry with nanomechanical systems

Sage, Eric and Brenac, Ariel and Alava, Thomas and Morel, Robert and Dupré, Cécilia and Hanay, Mehmet Selim and Roukes, Michael L. and Duraffourg, Laurent and Masselon, Christophe and Hentz, Sébastien (2015) Neutral particle mass spectrometry with nanomechanical systems. Nature Communications, 6 (3). Art. No. 6482. ISSN 2041-1723. PMCID PMC4366497. https://resolver.caltech.edu/CaltechAUTHORS:20150505-091144707

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Abstract

Current approaches to mass spectrometry (MS) require ionization of the analytes of interest. For high-mass species, the resulting charge state distribution can be complex and difficult to interpret correctly. Here, using a setup comprising both conventional time-of-flight MS (TOF-MS) and nano-electromechanical systems-based MS (NEMS-MS) in situ, we show directly that NEMS-MS analysis is insensitive to charge state: the spectrum consists of a single peak whatever the species’ charge state, making it significantly clearer than existing MS analysis. In subsequent tests, all the charged particles are electrostatically removed from the beam, and unlike TOF-MS, NEMS-MS can still measure masses. This demonstrates the possibility to measure mass spectra for neutral particles. Thus, it is possible to envisage MS-based studies of analytes that are incompatible with current ionization techniques and the way is now open for the development of cutting-edge system architectures with unique analytical capability.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/ncomms7482DOIArticle
https://rdcu.be/bJ2jPPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366497/PubMed CentralArticle
https://arxiv.org/abs/1405.7281arXivDiscussion Paper
ORCID:
AuthorORCID
Dupré, Cécilia0000-0001-5096-1983
Hanay, Mehmet Selim0000-0002-1928-044X
Roukes, Michael L.0000-0002-2916-6026
Duraffourg, Laurent0000-0002-9829-9295
Masselon, Christophe0000-0003-0117-2480
Hentz, Sébastien0000-0003-0479-9027
Additional Information:© 2015 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. Received 09 January 2015. Accepted 02 February 2015. Published 10 March 2015. We acknowledge partial support from the LETI Carnot Institute NEMS-MS project. We also thank Carine Marcoux for her support with the device fabrication, A.-K. Stark for technical discussions as well as Professor Jean-Claude Tabet for his advice on the writing of the manuscript. S.H. would like to thank Professor Dan Frost for carefully proofreading the text.
Funders:
Funding AgencyGrant Number
LETI Carnot InstituteUNSPECIFIED
Issue or Number:3
PubMed Central ID:PMC4366497
Record Number:CaltechAUTHORS:20150505-091144707
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150505-091144707
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57219
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 May 2015 16:41
Last Modified:03 Oct 2019 08:22

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