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Studies on C3a_(hu) Binding to Human Eosinophils: Characterization of Binding

Goers, John W. and Glovsky, M. Michael and Hunkapiller, M. W. and Farnsworth, V. and Richards, J. H. (1984) Studies on C3a_(hu) Binding to Human Eosinophils: Characterization of Binding. International Archives of Allergy and Applied Immunology, 74 (2). pp. 147-151. ISSN 0020-5915. doi:10.1159/000233535.

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C3a purified to chemical homogeneity from human serum binds preferentially to human eosinophils > neutrophils. Little or no binding is found with human platelets. Maximum binding to eosinophils at 37 °C occurs within 15 min. Dilution of ^(125)I-C3a by either cold C3a or washing away unbound ^(125)I-C3a and reincubating at 37 °C reveals a T_(1/2) of ∼30 min. C3a_(desArg) neither binds to eosinophils nor inhibits the binding of ^(125)I-C3a. The binding of C3a to human eosinophils may reflect a physiologic role of C3a in eosinophil motility or function.

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Additional Information:© 1984 S. Karger AG, Basel. Received: July 11, 1983. We are grateful to Lucette Ghekiere for her technical assistance and to Marijo Dowling for secretarial skills. These studies were supported by Southern California Permanente Medical Group and Kaiser Foundation Hospitals Grant No. 17.
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Southern California Permanente Medical GroupUNSPECIFIED
Kaiser Foundation Hospitals Grant17
Issue or Number:2
Record Number:CaltechAUTHORS:20150505-115820659
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Official Citation:Studies on C3ahu Binding to Human Eosinophils: Characterization of Binding Goers J.W. · Glovsky M.M. · Hunkapiller M.W. · Farnsworth V. · Richards J.H. Int Arch Allergy Immunol 1984;74:147–151 (DOI:10.1159/000233535)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57234
Deposited By: Ruth Sustaita
Deposited On:06 May 2015 14:46
Last Modified:10 Nov 2021 21:10

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