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Studies of Protein Function by Various Mutagenic Strategies: β-Lactamase

Dalbadie-McFarland, G. and Neitzel, J. and Riggs, A. D. and Richards, J. H. (1984) Studies of Protein Function by Various Mutagenic Strategies: β-Lactamase. Annals of the New York Academy of Sciences, 434 . pp. 232-238. ISSN 0077-8923. https://resolver.caltech.edu/CaltechAUTHORS:20150505-154055761

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Abstract

Structure unambiguously determines the function of proteins; the linear amino acid sequence in turn dictates three-dimensional structure. Important insights into the molecular origins of the functional behavior of a particular protein become possible if one can alter in prescribed ways the structure of that protein, thereby allowing one to undertake structure-function studies of the type that have a long history of success in organic and pharmaceutical chemistry. Changes in the structure of a protein can be most expeditiously accomplished by appropriate changes in the base sequence of the DNA encoding that protein.


Item Type:Article
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URLURL TypeDescription
http://dx.doi.org/10.1111/j.1749-6632.1984.tb29833.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1984.tb29833.x/abstractPublisherArticle
Additional Information:© 1984 John Wiley & Sons, Inc. This work was supported by the following grants: NIH GM 16424 and ONR N00014-83-K-0487.
Funders:
Funding AgencyGrant Number
NIHGM 16424
Office of Naval Research (ONR)N00014-83-K-0487
Record Number:CaltechAUTHORS:20150505-154055761
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150505-154055761
Official Citation:Dalbadie-mcfarland, G., Neitzel, J., Riggs, A. D., & Richards, J. H. (1984). Studies of Protein Function by Various Mutagenic Strategies: β-Lactamasea. Annals of the New York Academy of Sciences, 434(1), 232-238. doi: 10.1111/j.1749-6632.1984.tb29833.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57248
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:06 May 2015 14:33
Last Modified:03 Oct 2019 08:22

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