Dalbadie-McFarland, G. and Neitzel, J. and Riggs, A. D. and Richards, J. H. (1984) Studies of Protein Function by Various Mutagenic Strategies: β-Lactamase. Annals of the New York Academy of Sciences, 434 . pp. 232-238. ISSN 0077-8923. doi:10.1111/j.1749-6632.1984.tb29833.x. https://resolver.caltech.edu/CaltechAUTHORS:20150505-154055761
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Abstract
Structure unambiguously determines the function of proteins; the linear amino acid sequence in turn dictates three-dimensional structure. Important insights into the molecular origins of the functional behavior of a particular protein become possible if one can alter in prescribed ways the structure of that protein, thereby allowing one to undertake structure-function studies of the type that have a long history of success in organic and pharmaceutical chemistry. Changes in the structure of a protein can be most expeditiously accomplished by appropriate changes in the base sequence of the DNA encoding that protein.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1984 John Wiley & Sons, Inc. This work was supported by the following grants: NIH GM 16424 and ONR N00014-83-K-0487. | |||||||||
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| DOI: | 10.1111/j.1749-6632.1984.tb29833.x | |||||||||
| Record Number: | CaltechAUTHORS:20150505-154055761 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150505-154055761 | |||||||||
| Official Citation: | Dalbadie-mcfarland, G., Neitzel, J., Riggs, A. D., & Richards, J. H. (1984). Studies of Protein Function by Various Mutagenic Strategies: β-Lactamasea. Annals of the New York Academy of Sciences, 434(1), 232-238. doi: 10.1111/j.1749-6632.1984.tb29833.x | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57248 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Joanne McCole | |||||||||
| Deposited On: | 06 May 2015 14:33 | |||||||||
| Last Modified: | 10 Nov 2021 21:10 |
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