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Synthetic metalloproteins

Tomich, John M. and Richards, John H. (1992) Synthetic metalloproteins. In: Peptides: Chemistry and Biology. ESCOM , Leiden, pp. 431-432. ISBN 9789072199126.

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With the success of chemical syntheses and purification of large polypeptides ( > 50 amino acid residues) attention now focuses on developing protocols to correctly fold these products to generate species with high levels of bioactivity. The art of 'breathing life' into these molecules requires denaturation/renaturation, reduction/oxidation of sulfhydryls and assembly of holoproteins from apo-forms. We outline herein some of the strategies employed to assemble metalloproteins with activities essentially identical to that of their native counterparts.

Item Type:Book Section
Additional Information:© 1992 ESCOM. We greatly acknowledge the participation of Dr. Takeo Iwamoto who assisted in the chemical synthesis of the polypeptides and Drs. Eugene Smith, Benjamin Feinberg, and C. Frank Shaw III who performed the biophysical characterizations.
Record Number:CaltechAUTHORS:20150506-085259870
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57256
Deposited By: Tony Diaz
Deposited On:06 May 2015 16:20
Last Modified:03 Oct 2019 08:22

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