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Role of Acetate in Biosynthesis

Richards, John H. (1963) Role of Acetate in Biosynthesis. Antimicrobial Agents and Chemotherapy, 161 . pp. 349-351. ISSN 0066-4804.

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The role of acetate in the biosynthesis of a large number of antibiotics and other natural products is discussed. Included are simple substances apparently derived from acetate by molecular rearrangements, such as patulin and the fungal tropolone acids, puberlonic and stipitatic acids. The origin of more complex antibiotics such as oxytetracycline is considered, as well as the genesis of depsidones (such as nidulin) from lichens and fungi. The involvement of acetate in the biosynthesis of various classes of alkaloids, such as the indoles, strychnine, and ajmaline, is also discussed. More recent developments in the biochemical details of these processes, such as the role of malonate, is particularly stressed.

Item Type:Article
Additional Information:© 1963 American Society for Microbiology.
Funding AgencyGrant Number
Alfred P. Sloan FoundationUNSPECIFIED
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Caltech Gates and Crellin Laboratories of Chemistry3052
Record Number:CaltechAUTHORS:20150506-092654869
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57258
Deposited By: Tony Diaz
Deposited On:06 May 2015 17:09
Last Modified:03 Oct 2019 08:22

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