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Reagents for the site-specific cleavage of megabase DNA

Dervan, Peter B. (1992) Reagents for the site-specific cleavage of megabase DNA. Nature, 359 (6390). pp. 87-88. ISSN 0028-0836. doi:10.1038/359087a0.

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The physical mapping of chromosomes will be facilitated by methods of breaking large DNA into manageable fragments, or cutting uniquely at genetic markers of interest. Key issues in the design of sequence-specific DNA cleaving reagents are the specificity of binding, the number of different sequences that can be targeted and the cleavage yield.

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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1992 Nature Publishing Group.
Issue or Number:6390
Record Number:CaltechAUTHORS:20150512-104607313
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57449
Deposited By: Tony Diaz
Deposited On:12 May 2015 17:49
Last Modified:10 Nov 2021 21:50

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