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Reagents for the site-specific cleavage of megabase DNA

Dervan, Peter B. (1992) Reagents for the site-specific cleavage of megabase DNA. Nature, 359 (6390). pp. 87-88. ISSN 0028-0836. doi:10.1038/359087a0. https://resolver.caltech.edu/CaltechAUTHORS:20150512-104607313

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Abstract

The physical mapping of chromosomes will be facilitated by methods of breaking large DNA into manageable fragments, or cutting uniquely at genetic markers of interest. Key issues in the design of sequence-specific DNA cleaving reagents are the specificity of binding, the number of different sequences that can be targeted and the cleavage yield.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/359087a0 DOIArticle
http://www.nature.com/nature/journal/v359/n6390/abs/359087a0.htmlPublisherArticle
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1992 Nature Publishing Group.
Issue or Number:6390
DOI:10.1038/359087a0
Record Number:CaltechAUTHORS:20150512-104607313
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150512-104607313
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57449
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 May 2015 17:49
Last Modified:10 Nov 2021 21:50

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