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The gene lin-3 encodes an inductive signal for vulval development in C. elegans

Hill, Russell J. and Sternberg, Paul W. (1992) The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature, 358 (6386). pp. 470-476. ISSN 0028-0836. doi:10.1038/358470a0.

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The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-a and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.

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Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1992 Nature Publishing Group. Received 7 May: accepted 25 June 1992. We thank P. Tzou for technical assistance, A. Coulson and J. Sulston for the λ2001 genomic library and cosmids near the lin-3 locus; R. Waterston for YAC clones grids; I. Mori for RW7096; M. Chalfie for TU355; A. Rose and O. Bailie for map data; A. Fire for lacZ expression vectors and protocols; R. Barstead, C. Martin and S. Kim for cDNA libraries; P. Bjorkman. L. Kozar and E. Schwarz for help with sequence analysis; L. Carta and L. Huang for sharing unpublished results; and members of our laboratory, O. Anderson and E. Schwarz for their comments on the manuscript. This work was supported by a USPHS grant and a Searle Scholar Award to P.W.S. P.W.S. is an investigator of the Howard Hughes Medical Institute. R.J.H. was an NSF predoctoral fellow.
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U.S. Public Health Service (USPHS)UNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NSF Predoctoral FellowshipUNSPECIFIED
Issue or Number:6386
Record Number:CaltechAUTHORS:20150512-124029795
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57457
Deposited By: Tony Diaz
Deposited On:12 May 2015 21:56
Last Modified:10 Nov 2021 21:50

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