Hill, Russell J. and Sternberg, Paul W. (1992) The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature, 358 (6386). pp. 470-476. ISSN 0028-0836. doi:10.1038/358470a0. https://resolver.caltech.edu/CaltechAUTHORS:20150512-124029795
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Abstract
The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-a and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.
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| Additional Information: | © 1992 Nature Publishing Group. Received 7 May: accepted 25 June 1992. We thank P. Tzou for technical assistance, A. Coulson and J. Sulston for the λ2001 genomic library and cosmids near the lin-3 locus; R. Waterston for YAC clones grids; I. Mori for RW7096; M. Chalfie for TU355; A. Rose and O. Bailie for map data; A. Fire for lacZ expression vectors and protocols; R. Barstead, C. Martin and S. Kim for cDNA libraries; P. Bjorkman. L. Kozar and E. Schwarz for help with sequence analysis; L. Carta and L. Huang for sharing unpublished results; and members of our laboratory, O. Anderson and E. Schwarz for their comments on the manuscript. This work was supported by a USPHS grant and a Searle Scholar Award to P.W.S. P.W.S. is an investigator of the Howard Hughes Medical Institute. R.J.H. was an NSF predoctoral fellow. | ||||||||||
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| Issue or Number: | 6386 | ||||||||||
| DOI: | 10.1038/358470a0 | ||||||||||
| Record Number: | CaltechAUTHORS:20150512-124029795 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150512-124029795 | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 57457 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | Tony Diaz | ||||||||||
| Deposited On: | 12 May 2015 21:56 | ||||||||||
| Last Modified: | 10 Nov 2021 21:50 |
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