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Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes

Company, Mahshid and Arenas, Jaime and Abelson, John (1991) Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes. Nature, 349 (6309). pp. 487-493. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150513-103110652

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Abstract

The product of the yeast PRP22 gene acts late in the splicing of yeast pre-messenger RNA, mediating the release of the spliced mRNA from the spliceosome. The predicted PRP22 protein sequence shares extensive homology with that of PRP2 and PRP16 proteins, which are also involved in nuclear pre-mRNA splicing. The homologous region contains sequence elements characteristic of several demonstrated or putative ATP-dependent RNA helicases. A putative RNA-binding motif originally identified in bacterial ribosomal protein SI and Escherichia coli polynucleotide phosphorylase has also been found in PRP22.


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http://dx.doi.org/10.1038/349487a0DOIArticle
http://www.nature.com/nature/journal/v349/n6309/abs/349487a0.htmlPublisherArticle
Additional Information:© 1991 Nature Publishing Group. Received 21 November; accepted 11 December 1990. We thank M. Gribskov for his assistance on the use of PROFILE SEARCH Program, and T.-H. Chang and C. O'Day for comments on the manuscript. This work was supported by NIH (J.A.)
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Issue or Number:6309
Record Number:CaltechAUTHORS:20150513-103110652
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150513-103110652
Official Citation:Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes 487 Mahshid Company, Jaime Arenas & John Abelson doi:10.1038/349487a0
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57491
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 May 2015 17:44
Last Modified:03 Oct 2019 08:25

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