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The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

Aroian, Raffi V. and Koga, Makoto and Mendel, Jane E. and Ohshima, Yasumi and Sternberg, Paul W. (1990) The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature, 348 (6303). pp. 693-699. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20150513-111306779

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Abstract

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/348693a0DOIArticle
http://www.nature.com/nature/journal/v348/n6303/abs/348693a0.htmlPublisherArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1990 Nature Publishing Group. Received 5 November; accepted 14 November 1990. We thank J. Sulston and A. Coulson (MRC, United Kingdom) for physical mapping of kin-7 and the gifts of cosmid clones, C. Link for the genomic library. R. Barstead for the cDNA library and protocols, R. Waterston for YACs, A. Papp for a mapping strain, J. Kramer and J. Park for mapping information, I Mori, t. Tani, P. Tsoulfas, M. Han and members of our laboratories for suggestions and discussions, and A. Holboke, J. Luxemburg and P. Tzou for technical assistance. This work was supported by US Public Health Service (P.W.S.) and the Ministry of Education, Science and Culture of Japan (Y.O.)
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)UNSPECIFIED
Ministry of Education, Science and Culture (Japan)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:6303
Record Number:CaltechAUTHORS:20150513-111306779
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150513-111306779
Official Citation:The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily 693 Raffi V. Aroian, Makoto Koga, Jane E. Mendel, Yasumi Ohshima & Paul W. Sternberg doi:10.1038/348693a0
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57497
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 May 2015 18:40
Last Modified:03 Oct 2019 08:25

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