Aroian, Raffi V. and Koga, Makoto and Mendel, Jane E. and Ohshima, Yasumi and Sternberg, Paul W. (1990) The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature, 348 (6303). pp. 693-699. ISSN 0028-0836. doi:10.1038/348693a0. https://resolver.caltech.edu/CaltechAUTHORS:20150513-111306779
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Abstract
The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.
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| Additional Information: | © 1990 Nature Publishing Group. Received 5 November; accepted 14 November 1990. We thank J. Sulston and A. Coulson (MRC, United Kingdom) for physical mapping of kin-7 and the gifts of cosmid clones, C. Link for the genomic library. R. Barstead for the cDNA library and protocols, R. Waterston for YACs, A. Papp for a mapping strain, J. Kramer and J. Park for mapping information, I Mori, t. Tani, P. Tsoulfas, M. Han and members of our laboratories for suggestions and discussions, and A. Holboke, J. Luxemburg and P. Tzou for technical assistance. This work was supported by US Public Health Service (P.W.S.) and the Ministry of Education, Science and Culture of Japan (Y.O.) | |||||||||
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| Issue or Number: | 6303 | |||||||||
| DOI: | 10.1038/348693a0 | |||||||||
| Record Number: | CaltechAUTHORS:20150513-111306779 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150513-111306779 | |||||||||
| Official Citation: | The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily 693 Raffi V. Aroian, Makoto Koga, Jane E. Mendel, Yasumi Ohshima & Paul W. Sternberg doi:10.1038/348693a0 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57497 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 13 May 2015 18:40 | |||||||||
| Last Modified: | 10 Nov 2021 21:50 |
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