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Noelin-1 is a secreted glycoprotein involved in generation of the neural crest

Barembaum, Meyer and Moreno, Tanya A. and LaBonne, Carole and Sechrist, John and Bronner-Fraser, Marianne (2000) Noelin-1 is a secreted glycoprotein involved in generation of the neural crest. Nature Cell Biology, 2 (4). pp. 219-225. ISSN 1465-7392. doi:10.1038/35008643.

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The vertebrate neural crest arises at the border of the neural plate during early stages of nervous system development; however, little is known about the molecular mechanisms underlying neural crest formation. Here we identify a secreted protein, Noelin-1, which has the ability to prolong neural crest production. Noelin-1 messenger RNA is expressed in a graded pattern in the closing neural tube. It subsequently becomes restricted to the dorsal neural folds and migrating neural crest. Over expression of Noelin-1 using recombinant retroviruses causes an excess of neural crest emigration and extends the time that the neural tube is competent to generate as well as regenerate neural crest cells. These results support an important role for Noelin-1 in regulating the production of neural crest cells by the neural tube.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2000 Macmillan Publishers Limited. Received 4 January 2000; accepted 28 February 2000; published 8 March 2000. We thank C. Baker, S. Fraser, M. Dickinson, B. Murray and M. Selleck for helpful discussions and comments on the manuscript and J. Neri and R. Velasco for help with sectioning. This work was supported by NS 36585 and NS 34671. Correspondence and requests for materials should be addressed to M.B-F. Sequences for Noelin-1 and Noelin-2 have been deposited in GenBank (accession nos AF182815 and AF239804, respectively).
Funding AgencyGrant Number
NIHNS 36585
NIHNS 34671
Issue or Number:4
Record Number:CaltechAUTHORS:20150513-161849302
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Official Citation:Barembaum, M., Moreno, T. A., LaBonne, C., Sechrist, J., & Bronner-Fraser, M. (2000). Noelin-1 is a secreted glycoprotein involved in generation of the neural crest. [10.1038/35008643]. Nat Cell Biol, 2(4), 219-225.
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ID Code:57515
Deposited On:19 May 2015 02:48
Last Modified:10 Nov 2021 21:51

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