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Control of Brain Development, Function and Behavior by the Microbiome

Sampson, Timothy R. and Mazmanian, Sarkis K. (2015) Control of Brain Development, Function and Behavior by the Microbiome. Cell Host & Microbe, 17 (5). pp. 565-576. ISSN 1931-3128. PMCID PMC4442490.

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Animals share an intimate and life-long partnership with a myriad of resident microbial species, collectively referred to as the microbiota. Symbiotic microbes have been shown to regulate nutrition and metabolism and are critical for the development and function of the immune system. More recently, studies have suggested that gut bacteria can impact neurological outcomes—altering behavior and potentially affecting the onset and/or severity of nervous system disorders. In this review, we highlight emerging evidence that the microbiome extends its influence to the brain via various pathways connecting the gut to the central nervous system. While understanding and appreciation of a gut microbial impact on neurological function is nascent, unraveling gut-microbiome-brain connections holds the promise of transforming the neurosciences and revealing potentially novel etiologies for psychiatric and neurodegenerative disorders.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Sampson, Timothy R.0000-0002-2486-8766
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2015 Elsevier Inc. We apologize to those authors whose work we have failed to mention due to space constraints. We would like to thank Hannah Ratner, Catherine Schretter, Dr. Gil Sharon, and Dr. Wei-Li Wu for helpful discussions and critical review of this manuscript. Research in the Mazmanian laboratory is funded by grants from the National Institutes of Health (MH100556, DK078938, and NS085910), the Heritage Medical Research Institute, the Emerald Foundation, Autism Speaks, and the Simons Foundation.
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
Emerald FoundationUNSPECIFIED
Simons FoundationUNSPECIFIED
Issue or Number:5
PubMed Central ID:PMC4442490
Record Number:CaltechAUTHORS:20150518-143833374
Persistent URL:
Official Citation:Timothy R. Sampson, Sarkis K. Mazmanian, Control of Brain Development, Function, and Behavior by the Microbiome, Cell Host & Microbe, Volume 17, Issue 5, 13 May 2015, Pages 565-576, ISSN 1931-3128, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57614
Deposited By: Tony Diaz
Deposited On:18 May 2015 21:57
Last Modified:24 Feb 2020 20:48

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