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Lessons from the immune system: From catalysis to materials science

Hsieh-Wilson, Linda C. and Xiang, Xiao-Dong and Schultz, Peter G. (1996) Lessons from the immune system: From catalysis to materials science. Accounts of Chemical Research, 29 (3). pp. 164-170. ISSN 0001-4842. http://resolver.caltech.edu/CaltechAUTHORS:20150519-094653417

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Abstract

Nature has produced a remarkable array of molecules that perform the complex processes of living organisms, from the immune response and catalysis to signal transduction and gene regulation. However, in contrast to chemists who typically synthesize and characterize a single molecule at a time, Nature draws upon a vast combinatorial library of precursor molecules and screens them for desired properties. Perhaps the most notable example of this strategy is the immune system, which is capable of generating tremendous molecular diversity via gene rearrangements and somatic mutation and screening this diversity for high-affinity, selective receptors to foreign antigens. This natural example of the power of combinatorial processes has inspired chemists and biochemists alike to apply this strategy to other problems, ranging from catalysis and drug discovery to materials science. In this Account, we will describe a number of ongoing efforts in our laboratory which may help to illustrate the potential of combinatorial libraries in chemistry.


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http://dx.doi.org/10.1021/ar950247eDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ar950247ePublisherArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 1996 American Chemical Society. Received November 15, 1995. We are grateful for financial support for this work from the National Institutes of Health, Office of Naval Research, and U.S. Department of Energy. P.G.S. is a Howard Hughes Medical Institute Investigator. L.C.H.-W. thanks the National Science Foundation and the American Chemical Society for predoctoral fellowships.
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NIHUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NSF Predoctoral FellowshipUNSPECIFIED
American Chemical Society UNSPECIFIED
Record Number:CaltechAUTHORS:20150519-094653417
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150519-094653417
Official Citation:Lessons from the Immune System:  From Catalysis to Materials Science Linda C. Hsieh-Wilson,Xiao-Dong Xiang, and, and Peter G. Schultz* Accounts of Chemical Research 1996 29 (3), 164-170 DOI: 10.1021/ar950247e
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57647
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 May 2015 17:56
Last Modified:07 Nov 2017 23:15

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