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A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth

Kalovidouris, Stacey A. and Gama, Cristal I. and Lee, Lori W. and Hsieh-Wilson, Linda C. (2005) A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth. Journal of the American Chemical Society, 127 (5). pp. 1340-1341. ISSN 0002-7863. doi:10.1021/ja044631v. https://resolver.caltech.edu/CaltechAUTHORS:20150519-101948364

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Abstract

We report a fucose α(1−2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1−2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucα(1−2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja044631v DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja044631vPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/ja044631vPublisherSupporting Information
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2005 American Chemical Society. Received September 3, 2004. We thank the Biological Imaging Center at Caltech for instrumentation. This research was supported by an NIH Training Grant (T32 GM08501), NIH (RO1 NS045061), and the Alfred P. Sloan Foundation.
Funders:
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32 GM08501
NIHRO1 NS045061
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:5
DOI:10.1021/ja044631v
Record Number:CaltechAUTHORS:20150519-101948364
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150519-101948364
Official Citation:A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth Stacey A. Kalovidouris,Cristal I. Gama,Lori W. Lee, and, and Linda C. Hsieh-Wilson Journal of the American Chemical Society 2005 127 (5), 1340-1341 DOI: 10.1021/ja044631v
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57652
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 May 2015 18:06
Last Modified:10 Nov 2021 21:53

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