A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth

Kalovidouris, Stacey A. and Gama, Cristal I. and Lee, Lori W. and Hsieh-Wilson, Linda C. (2005) A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth. Journal of the American Chemical Society, 127 (5). pp. 1340-1341. ISSN 0002-7863. doi:10.1021/ja044631v. https://resolver.caltech.edu/CaltechAUTHORS:20150519-101948364

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Abstract

We report a fucose α(1−2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1−2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucα(1−2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1021/ja044631v	DOI	Article
http://pubs.acs.org/doi/abs/10.1021/ja044631v	Publisher	Article
http://pubs.acs.org/doi/suppl/10.1021/ja044631v	Publisher	Supporting Information

ORCID:

Author	ORCID
Hsieh-Wilson, Linda C.	0000-0001-5661-1714

Additional Information:

© 2005 American Chemical Society. Received September 3, 2004. We thank the Biological Imaging Center at Caltech for instrumentation. This research was supported by an NIH Training Grant (T32 GM08501), NIH (RO1 NS045061), and the Alfred P. Sloan Foundation.

Funders:

Funding Agency	Grant Number
NIH Predoctoral Fellowship	T32 GM08501
NIH	RO1 NS045061
Alfred P. Sloan Foundation	UNSPECIFIED

Issue or Number:

DOI:

10.1021/ja044631v

Record Number:

CaltechAUTHORS:20150519-101948364

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20150519-101948364

Official Citation:

A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth Stacey A. Kalovidouris,Cristal I. Gama,Lori W. Lee, and, and Linda C. Hsieh-Wilson Journal of the American Chemical Society 2005 127 (5), 1340-1341 DOI: 10.1021/ja044631v

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ID Code:

57652

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

19 May 2015 18:06

Last Modified:

10 Nov 2021 21:53

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