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Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation

Lamarre-Vincent, Nathan and Hsieh-Wilson, Linda C. (2003) Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation. Journal of the American Chemical Society, 125 (22). pp. 6612-6613. ISSN 0002-7863. doi:10.1021/ja028200t.

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We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAF_(II)130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.

Item Type:Article
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URLURL TypeDescription DOIArticle Information InChemical & Engineering News: Science & Technology
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2003 American Chemical Society. Received August 19, 2002. We thank C. Gama, N. Khidekel, M. Shahgholi, and P. Snow for invaluable assistance, and R. Goodman, J. Hanover, and N. Tanese for providing cDNAs. We also gratefully acknowledge support from the Research Corporation and Beckman Young Investigators Program.
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Research CorporationUNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:22
Record Number:CaltechAUTHORS:20150519-103941237
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Official Citation:Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation Nathan Lamarre-Vincent and and Linda C. Hsieh-Wilson Journal of the American Chemical Society 2003 125 (22), 6612-6613 DOI: 10.1021/ja028200t
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57654
Deposited By: Tony Diaz
Deposited On:19 May 2015 17:59
Last Modified:10 Nov 2021 21:53

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