Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation

Lamarre-Vincent, Nathan and Hsieh-Wilson, Linda C. (2003) Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation. Journal of the American Chemical Society, 125 (22). pp. 6612-6613. ISSN 0002-7863. doi:10.1021/ja028200t. https://resolver.caltech.edu/CaltechAUTHORS:20150519-103941237

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Abstract

We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAF_(II)130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1021/ja028200t	DOI	Article
http://pubs.acs.org/doi/abs/10.1021/ja028200t	Publisher	Article
http://pubs.acs.org/doi/suppl/10.1021/ja028200t	Publisher	Supporting Information
http://pubs.acs.org/isubscribe/journals/cen/81/i22/html/8122scic.html	Featured In	Chemical & Engineering News: Science & Technology

ORCID:

Author	ORCID
Hsieh-Wilson, Linda C.	0000-0001-5661-1714

Additional Information:

© 2003 American Chemical Society. Received August 19, 2002. We thank C. Gama, N. Khidekel, M. Shahgholi, and P. Snow for invaluable assistance, and R. Goodman, J. Hanover, and N. Tanese for providing cDNAs. We also gratefully acknowledge support from the Research Corporation and Beckman Young Investigators Program.

Funders:

Funding Agency	Grant Number
Research Corporation	UNSPECIFIED
Arnold and Mabel Beckman Foundation	UNSPECIFIED

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DOI:

10.1021/ja028200t

Record Number:

CaltechAUTHORS:20150519-103941237

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20150519-103941237

Official Citation:

Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation Nathan Lamarre-Vincent and and Linda C. Hsieh-Wilson Journal of the American Chemical Society 2003 125 (22), 6612-6613 DOI: 10.1021/ja028200t

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ID Code:

57654

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

19 May 2015 17:59

Last Modified:

10 Nov 2021 21:53

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