Yan, Zhen and Hsieh-Wilson, Linda and Feng, Jian and Tomizawa, Kazuhito and Allen, Patrick B. and Fienberg, Allen A. and Nairn, Angus C. and Greengard, Paul (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP−32 and spinophilin. Nature Neuroscience, 2 (1). pp. 13-17. ISSN 1097-6256. doi:10.1038/4516. https://resolver.caltech.edu/CaltechAUTHORS:20150519-113011666
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Abstract
Modulation of AMPA−type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP−1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP−1 catalytic activity by DARPP−32, a dopamine− and cAMP−regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP−1 to spinophilin, a protein that colocalizes PP−1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP−1 is important for AMPA−receptor−mediated synaptic transmission and plasticity.
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| Additional Information: | © 1999 Nature America Inc. Received 14 October; Accepted 6 November 1998. We thank Takuo Watanabe for providing [^(32)P]phosphorylase a. This work was supported by a National Parkinson Foundation grant (Z.Y.) and U.S. Public Health Service Grants MH 40899 and DA 10044 (P.G.). | |||||||||
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| Issue or Number: | 1 | |||||||||
| DOI: | 10.1038/4516 | |||||||||
| Record Number: | CaltechAUTHORS:20150519-113011666 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150519-113011666 | |||||||||
| Official Citation: | Yan, Z., Hsieh-Wilson, L., Feng, J., Tomizawa, K., Allen, P. B., Fienberg, A. A., . . . Greengard, P. (1999). Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. [10.1038/4516]. Nat Neurosci, 2(1), 13-17. | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57658 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | INVALID USER | |||||||||
| Deposited On: | 19 May 2015 19:00 | |||||||||
| Last Modified: | 10 Nov 2021 21:53 |
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