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Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP−32 and spinophilin

Yan, Zhen and Hsieh-Wilson, Linda and Feng, Jian and Tomizawa, Kazuhito and Allen, Patrick B. and Fienberg, Allen A. and Nairn, Angus C. and Greengard, Paul (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP−32 and spinophilin. Nature Neuroscience, 2 (1). pp. 13-17. ISSN 1097-6256. doi:10.1038/4516. https://resolver.caltech.edu/CaltechAUTHORS:20150519-113011666

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Abstract

Modulation of AMPA−type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP−1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP−1 catalytic activity by DARPP−32, a dopamine− and cAMP−regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP−1 to spinophilin, a protein that colocalizes PP−1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP−1 is important for AMPA−receptor−mediated synaptic transmission and plasticity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/4516DOIArticle
http://www.nature.com/neuro/journal/v2/n1/full/nn0199_13.htmlPublisherArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda0000-0001-5661-1714
Additional Information:© 1999 Nature America Inc. Received 14 October; Accepted 6 November 1998. We thank Takuo Watanabe for providing [^(32)P]phosphorylase a. This work was supported by a National Parkinson Foundation grant (Z.Y.) and U.S. Public Health Service Grants MH 40899 and DA 10044 (P.G.).
Funders:
Funding AgencyGrant Number
National Parkinson FoundationUNSPECIFIED
NIHMH40899
NIHDA10044
Issue or Number:1
DOI:10.1038/4516
Record Number:CaltechAUTHORS:20150519-113011666
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150519-113011666
Official Citation:Yan, Z., Hsieh-Wilson, L., Feng, J., Tomizawa, K., Allen, P. B., Fienberg, A. A., . . . Greengard, P. (1999). Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin. [10.1038/4516]. Nat Neurosci, 2(1), 13-17.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57658
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:19 May 2015 19:00
Last Modified:10 Nov 2021 21:53

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