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Progress toward an Antibody Glycosidase

Yu, Jaehoon and Hsieh-Wilson, Linda C. and Kochersperger, Lynn and Yonkovich, Shirlee and Stephans, James C. and Gallop, Mark A. and Schultz, Peter G. (1994) Progress toward an Antibody Glycosidase. Angewandte Chemie-International Edition In English, 33 (3). pp. 339-341. ISSN 0570-0833.

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The piperidine-based hapten 1 generates monoclonal antibodies that catalyze the hydrolysis of substrate 2 at pH5.5 (k_(cal) = 0.904 h^(−1), K_M = 324 μM). Hapten 1 is a competitive inhibitor of the antibody-catalyzed reaction. These results are significant for the development of antibodies for the sequence-specific hydrolysis of oligosaccharides.

Item Type:Article
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Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 1994 VCH Verlagsgesellschaft mbH. Received September 20, 1993. This work was supported by the Office of Naval Research (Grant No. N00014-91-J-I 130) and the Assistant Secretary for Conservation and Renewable Energy, Advanced Industrial Concepts Division of the U.S. Department of Energy (Contract No. DE-AC03-76SF00098). L C. H. is supported by a National Science Foundation Graduate Fellowship. We thank Holly C. Wessling for her assistance.
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-91-J-1130
Department of Energy (DOE)DE-AC03-76SF00098
NSF Graduate Research FellowshipUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20150519-122534441
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Official Citation:Yu, J., Hsieh, L. C., Kochersperger, L., Yonkovich, S., Stephans, J. C., Gallop, M. A., & Schultz, P. G. (1994). Progress toward an Antibody Glycosidase. Angewandte Chemie International Edition in English, 33(3), 339-341. doi: 10.1002/anie.199403391
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57659
Deposited By: Joanne McCole
Deposited On:19 May 2015 21:33
Last Modified:03 Oct 2019 08:27

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