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An Efficient Antibody-Catalyzed Oxygenation Reaction

Hsieh-Wilson, Linda C. and Stephans, James C. and Schultz, Peter G. (1994) An Efficient Antibody-Catalyzed Oxygenation Reaction. Journal of the American Chemical Society, 116 (5). pp. 2167-2168. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20150519-145451315

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Abstract

Biological oxygen-transfer reactions are essential for the biosynthesis of steroids and neurotransmitters, the degradation of endogenous substances, and the detoxification of xenobiotics. The monooxygenase enzymes responsible for these transformations require biological cofactors such as flavin, heme and nonheme iron, copper, or pterin and typically utilize NADPH for cofactor regeneration. Given their biological and chemical importance, oxygenation reactions have long been targets for antibody catalysis, and in a few cases, redox-active heme and flavin-dependent antibodies have been characterized. More recently, a new strategy has emerged for the generation of catalytic antibodies which utilizes unnatural, chemical cofactor. We now report an antibody-catalyzed sulfide oxygenation reaction mediated by the chemical cofactor sodium periodate, with turnover numbers similar to those of the corresponding enzymatic reactions (Scheme 1).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00084a076DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00084a076PublisherArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 1994 American Chemical Society. Financial support was provided by the Assistant Secretary for Conservation and Renewable Energy, Advanced Industrial Concepts Division of the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. L.C.H. gratefully acknowledges the support of the NSF (1990-1993) and SmithKline Beecham for an ACS Organic Chemistry Graduate Fellowship (1993-1994).
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC03-76SF00098
NSFUNSPECIFIED
Smithkline BeechamUNSPECIFIED
American Chemical SocietyUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20150519-145451315
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150519-145451315
Official Citation:Hsieh, L. C., Stephans, J. C., & Schultz, P. G. (1994). An Efficient Antibody-Catalyzed Oxygenation Reaction. Journal of the American Chemical Society, 116(5), 2167-2168. doi: 10.1021/ja00084a076
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57673
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:20 May 2015 18:36
Last Modified:03 Oct 2019 08:27

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