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Chemical approaches to understanding O-GlcNAc glycosylation in the brain

Rexach, Jessica E. and Clark, Peter M. and Hsieh-Wilson, Linda C. (2008) Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nature Chemical Biology, 4 (2). pp. 97-106. ISSN 1552-4450. PMCID PMC3250351. doi:10.1038/nchembio.68.

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O-GlcNAc glycosylation is a unique, dynamic form of glycosylation found on intracellular proteins of all multicellular organisms. Studies suggest that O-GlcNAc represents a key regulatory modification in the brain, contributing to transcriptional regulation, neuronal communication and neurodegenerative disease. Recently, several new chemical tools have been developed to detect and study the modification, including chemoenzymatic tagging methods, quantitative proteomics strategies and small-molecule inhibitors of O-GlcNAc enzymes. Here we highlight some of the emerging roles for O-GlcNAc in the nervous system and describe how chemical tools have significantly advanced our understanding of the scope, functional significance and cellular dynamics of this modification.

Item Type:Article
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Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2008 Nature Publishing Group. Published online 17 January 2008. We thank C.J. Rogers and H.E. Murrey for critical reading of the manuscript. This work was supported in part by grants from the US National Institutes of Health (RO1 GM084724 and F31 NS056525-02 to J.E.R.) and the US National Science Foundation (CHE-0239861).
Funding AgencyGrant Number
NIHRO1 GM084724-05
NIH Postdoctoral FellowshipF31 NS056525-02
Issue or Number:2
PubMed Central ID:PMC3250351
Record Number:CaltechAUTHORS:20150520-084336469
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57686
Deposited By: Tony Diaz
Deposited On:20 May 2015 16:14
Last Modified:10 Nov 2021 21:53

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