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Hepatic Lipidosis in a Research Colony of Big Brown Bats (Eptesicus fuscus)

Snyder, Jessica M. and Treuting, Piper M. and Brabb, Thea and Miller, Kimberly E. and Covey, Ellen and Lencioni, Karen C. (2015) Hepatic Lipidosis in a Research Colony of Big Brown Bats (Eptesicus fuscus). Comparative Medicine, 62 (2). pp. 133-139. ISSN 1532-0820. PMCID PMC4408899.

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During a nearby construction project, a sudden decrease in food intake and guano production occurred in an outdoor colony of big brown bats (Eptesicus fuscus), and one animal was found dead. Investigation revealed that the project was generating a large amount of noise and vibration, which disturbed the bats' feeding. Consequently the bats were moved into an indoor enclosure away from the construction noises, and the colony resumed eating. Over the next 3 wk, additional animals presented with clinical signs of lethargy, weight loss, ecchymoses, and icterus and were necropsied. Gross necropsy of the affected bats revealed large, pale yellow to tan, friable livers with rounded edges that floated when placed in 10% neutral-buffered formalin. Some bats had ecchymoses on the webbing and skin and gross perirenal hemorrhage. Histologic examination showed hepatic and renal tubular lipidosis. The clinical and pathologic signs of hemorrhage and icterus were suggestive of hepatic failure. Hepatic lipidosis was attributed to stress and inappetence associated with environmental perturbations. Once the environmental stressor was removed, the colony morbidity and mortality decreased. However, 2 y later, a series of new environmental stressors triggered additional deaths associated with hepatic lipidosis. Over a 9-y period, 21 cases of hepatic lipidosis were diagnosed in this bat colony.

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Additional Information:© 2015 Publishing Technology. Received: 12 July 2014; Revision requested: 18 September 2014; Accepted: 03 December 2014. We acknowledge Douglas Fitts for his advice regarding statistical analysis.
Issue or Number:2
PubMed Central ID:PMC4408899
Record Number:CaltechAUTHORS:20150520-093013669
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57693
Deposited By: Jason Perez
Deposited On:20 May 2015 23:18
Last Modified:03 Oct 2019 08:27

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