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Control of protein phosphatase I in the dendrite

Allen, P. B. and Hsieh-Wilson, Linda C. and Yan, Z. and Feng, J. and Ouimet, C. C. and Greengard, P. (1999) Control of protein phosphatase I in the dendrite. Biochemical Society Transactions, 27 (4). pp. 543-546. ISSN 1470-8752. https://resolver.caltech.edu/CaltechAUTHORS:20150520-093826100

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Abstract

Communication between nerve cells is mediated by both electrical and chemical signals. Chemical neurotransmission can be further categorized into fast and slow components. Fast acting neurotransmitters directly influence neuronal electrical excitability by binding to cell surface receptors which serve as ligand-gated ion channels, thereby directly modulating membrane potential and cell firing. Neurotransmitter receptors may otherwise modulate neuronal excitability indirectly, by coupling to intracellular signalling pathways that impact on the functional activity of ligand- and voltage-gated ion channels, ion pumps, and the machinery for chemical neurotransmission. These indirect actions are relatively slow, and often involve cascades of protein phosphorylation which serve to alter the biochemical activities of substrate proteins, and hence cellular physiology.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1042/bst0270543DOIArticle
http://www.biochemsoctrans.org/bst/027/bst0270543.htmPublisherArticle
ORCID:
AuthorORCID
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 1999 Biochemical Society. Received 1 January 1999.
Issue or Number:4
Record Number:CaltechAUTHORS:20150520-093826100
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150520-093826100
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57696
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:20 May 2015 18:58
Last Modified:03 Oct 2019 08:27

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