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Control of protein phosphatase I in the dendrite

Allen, P. B. and Hsieh-Wilson, Linda C. and Yan, Z. and Feng, J. and Ouimet, C. C. and Greengard, P. (1999) Control of protein phosphatase I in the dendrite. Biochemical Society Transactions, 27 (4). pp. 543-546. ISSN 1470-8752. doi:10.1042/bst0270543.

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Communication between nerve cells is mediated by both electrical and chemical signals. Chemical neurotransmission can be further categorized into fast and slow components. Fast acting neurotransmitters directly influence neuronal electrical excitability by binding to cell surface receptors which serve as ligand-gated ion channels, thereby directly modulating membrane potential and cell firing. Neurotransmitter receptors may otherwise modulate neuronal excitability indirectly, by coupling to intracellular signalling pathways that impact on the functional activity of ligand- and voltage-gated ion channels, ion pumps, and the machinery for chemical neurotransmission. These indirect actions are relatively slow, and often involve cascades of protein phosphorylation which serve to alter the biochemical activities of substrate proteins, and hence cellular physiology.

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Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 1999 Biochemical Society. Received 1 January 1999.
Issue or Number:4
Record Number:CaltechAUTHORS:20150520-093826100
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57696
Deposited On:20 May 2015 18:58
Last Modified:10 Nov 2021 21:53

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