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Refractive index measurement using an optical cavity based biosensor with a differential detection

Cho, SaiHim and Brake, Joshua H. and Joy, Cody and Kim, Seunghyun (2015) Refractive index measurement using an optical cavity based biosensor with a differential detection. In: Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics. Proceedings of SPIE. No.9332. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 93320Z. ISBN 978-1-62841-422-6. https://resolver.caltech.edu/CaltechAUTHORS:20150526-084537732

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Abstract

We proposed a low cost optical cavity based biosensor with a differential detection for point-of-care diagnosis. Two lasers at different wavelengths are used for the differential detection. This method enhances the sensitivity through higher responsivity and noise cancelation. To reduce noise further, especially due to the unstable low cost laser diode output, we employed a referencing method in which a reference pixel value in each CMOS image frame is subtracted from all other pixels. To validate the designed structure and demonstrate the sensitivity of it, we perform refractive index measurements of fluids with our design. In this presentation, we will discuss our design, simulation results, and measurement results.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2079300 DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2198673PublisherArticle
Additional Information:© 2015 SPIE.
Subject Keywords:point-of-care, biosensor, optical cavity, differential detection, referencing method, noise cancelation, refractive index
Series Name:Proceedings of SPIE
Issue or Number:9332
Record Number:CaltechAUTHORS:20150526-084537732
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150526-084537732
Official Citation:SaiHim Cho ; Joshua H. Brake ; Cody Joy ; Seunghyun Kim; Refractive index measurement using an optical cavity based biosensor with a differential detection. Proc. SPIE 9332, Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics, 93320Z (March 9, 2015); doi:10.1117/12.2079300
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:57793
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 May 2015 19:19
Last Modified:03 Oct 2019 08:28

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