Aldrich, Carta J. and Hammer, Robert E. and Jones-Youngblood, Sharon and Koszinowski, Ulrich and Hood, Lee and Stroynowski, Iwona and Forman, James (1991) Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules. Nature, 352 (6337). pp. 718-721. ISSN 0028-0836. doi:10.1038/352718a0. https://resolver.caltech.edu/CaltechAUTHORS:20150601-142904818
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Abstract
THE α1 and α2 domains of major histocompatibility complex (MHC) class I molecules function in the binding and presentation of foreign peptides to the T-cell antigen receptor and control both negative and positive selection of the T-cell repertoire. Although the α3 domain of class I is not involved in peptide binding, it does interact with the T-cell accessory molecule, CDS. CDS is important in the selection of T cells as anti-CDS antibody injected into perinatal mice interfers with this process. We previously used a hybrid class I molecule with the α1/α2 domains from L^d and the α3 domain from Q7^b and showed that this molecule binds an L^d-restricted peptide but does not interact with CD8-dependent cytotoxic T lymphocytes. Expression of this molecule in transgenic mice fails to negatively select a subpopulation of anti-L^d cytotoxic T lymphocytes. In addition, positive selection of virus-specific L^d-restricted cytotoxic T lymphocytes does not occur. We conclude that besides the α1/α2 domains of class I, the α3 domain plays an important part in both positive and negative selection of antigen-specific cells.
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| Additional Information: | © 1991 Nature Publishing Group. Received 26 March; Accepted 4 July 1991. This work was supported by an NIH grant (J.F.). We thank M. Zuniga for the L^d gene. G. D. Senn Ill for technical assistance, and B. Washington for secretarial help. | |||||||||
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| Issue or Number: | 6337 | |||||||||
| DOI: | 10.1038/352718a0 | |||||||||
| Record Number: | CaltechAUTHORS:20150601-142904818 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150601-142904818 | |||||||||
| Official Citation: | Aldrich, C. J., Hammer, R. E., Jones-Youngblood, S., Koszinowski, U., Hood, L., Stroynowski, I., & Forman, J. (1991). Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the [alpha]3 domain of MHC I molecules. [10.1038/352718a0]. Nature, 352(6337), 718-721. | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 57924 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | INVALID USER | |||||||||
| Deposited On: | 01 Jun 2015 22:40 | |||||||||
| Last Modified: | 10 Nov 2021 21:56 |
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